...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >An integrated approach to design novel therapeutic interventions for demyelinating disorders
【24h】

An integrated approach to design novel therapeutic interventions for demyelinating disorders

机译：设计脱髓鞘疾病的新疗法的综合方法

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Therapeutic strategies are often based on two general principles: interference with the pathogenic process and repair of the damaged tissues. Recent studies, however, have suggested that several pathological conditions may result from the interplay between genetic susceptibility traits and environmental influences that, by modulating the epigenome, also affect disease onset and progression. Based on lessons from neural development, it is conceivable that new lines of preventive and possibly therapeutic intervention might be developed to modulate disease onset or decrease the severity of the symptoms. This review will discuss these concepts within the context of multiple sclerosis, the most common demyelinating disease of the central nervous system, and the leading cause of progressive neurological disability in young adults.
机译：治疗策略通常基于两个基本原则：干扰致病过程和修复受损组织。然而，最近的研究表明，遗传易感性状与环境影响之间的相互作用可能会导致多种病理状况，而这些影响通过调节表观基因组，也会影响疾病的发作和进展。根据来自神经发育的经验教训，可以想象可能会开发出新的预防和可能的治疗干预措施，以调节疾病发作或减轻症状的严重程度。这篇综述将在多发性硬化，中枢神经系统最常见的脱髓鞘疾病以及年轻人进行性神经系统残疾的主要原因中讨论这些概念。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号