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首页> 外文期刊>The European Journal of Neuroscience >Corticotropin-releasing factor infusion into nucleus incertus suppresses medial prefrontal cortical activity and hippocampo-medial prefrontal cortical long-term potentiation
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Corticotropin-releasing factor infusion into nucleus incertus suppresses medial prefrontal cortical activity and hippocampo-medial prefrontal cortical long-term potentiation

机译：促肾上腺皮质激素释放因子的输注抑制了内侧额叶前皮质的活动和海马-内侧额叶前皮质的长期增强

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摘要

The medial prefrontal cortex (mPFC) in the rat has been implicated in a variety of cognitive processes, including working memory and expression of fear memory. We investigated the inputs from a brain stem nucleus, the nucleus incertus (NI), to the prelimbic area of the mPFC. This nucleus strongly expresses corticotropin-releasing factor type 1 (CRF1) receptors and responds to stress. A retrograde tracer was used to verify connections from the NI to the mPFC. Retrogradely labelled cells in the NI expressed CRF receptors. Electrophysiological manipulation of the NI revealed that stimulation of the NI inhibited spontaneous neuronal firing in the mPFC. Similarly, CRF infusion into the NI, in order to mimic a stressful condition, inhibited neuronal firing and burst firing in the mPFC. The effect of concurrent high-frequency stimulation of the NI on plasticity in the hippocampo-prelimbic medial prefrontal cortical (HP-mPFC) pathway was studied. It was found that electrical stimulation of the NI impaired long-term potentiation in the HP-mPFC pathway. Furthermore, CRF infusion into the NI produced similar results. These findings might account for some of the extra-pituitary functions of CRF and indicate that the NI may play a role in stress-driven modulation of working memory and possibly other cognitive processes subserved by the mPFC.
机译：大鼠的内侧前额叶皮层（mPFC）与多种认知过程有关，包括工作记忆和恐惧记忆的表达。我们调查了从脑干核，不安全核（NI）到mPFC的前缘区域的输入。该细胞核强烈表达促肾上腺皮质激素释放因子1（CRF1）受体，并对压力作出反应。逆行示踪剂用于验证从NI到mPFC的连接。 NI中逆行标记的细胞表达CRF受体。 NI的电生理操作显示，NI的刺激抑制了mPFC中的自发神经元放电。类似地，为了模拟压力状态，将CRF注入NI中可抑制mPFC中的神经元放电和爆发放电。研究了同时高频刺激NI对海马-前肢内侧前额叶皮层（HP-mPFC）通路可塑性的影响。发现NI的电刺激损害了HP-mPFC途径中的长期增强。此外，CRF输注至NI产生了相似的结果。这些发现可能解释了CRF的某些垂体外功能，并表明NI可能在压力驱动的工作记忆调节以及可能由mPFC支持的其他认知过程中发挥作用。

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