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首页> 外文期刊>The European Journal of Neuroscience >Visual cortex organisation in a macaque monkey with macular degeneration
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Visual cortex organisation in a macaque monkey with macular degeneration

机译：猕猴黄斑变性的视觉皮层组织

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The visual field is retinotopically represented in early visual areas. It has been suggested that when adult primary visual cortex (V1) is deprived of normal retinal input it is capable of large-scale reorganisation, with neurons inside the lesion projection zone (LPZ) being visually driven by inputs from intact retinal regions. Early functional magnetic resonance imaging (fMRI) studies in humans with macular degeneration (MD) report > 1 cm spread of activity inside the LPZ border, whereas recent results report no shift of the LPZ border. Here, we used fMRI population receptive field measurements to study, for the first time, the visual cortex organisation of one macaque monkey with MD and to compare it with normal controls. Our results showed that the border of the V1 LPZ remained stable, suggesting that the deafferented area V1 zone of the MD animal has limited capacity for reorganisation. Interestingly, the pRF size of non-deafferented V1 voxels increased slightly (~20% on average), although this effect appears weaker than that in previous single-unit recording reports. Area V2 also showed limited reorganisation. Remarkably, area V5/MT of the MD animal showed extensive activation compared to controls stimulated over the part of the visual field that was spared in the MD animal. Furthermore, population receptive field size distributions differed markedly in area V5/MT of the MD animal. Taken together, these results suggest that V5/MT has a higher potential for reorganisation after MD than earlier visual cortex.
机译：在早期的视觉区域中，视网膜在视网膜上代表了视野。已经提出，当成人初级视觉皮层（V1）被剥夺正常的视网膜输入时，它能够大规模重组，病变投影区域（LPZ）内的神经元受到来自完整视网膜区域输入的视觉驱动。在患有黄斑变性（MD）的人类中进行的早期功能磁共振成像（fMRI）研究表明，LPZ边界内的活动扩展> 1 cm，而最近的结果表明LPZ边界没有移位。在这里，我们首次使用fMRI群体感受野测量技术来研究一只猕猴与MD的视觉皮层组织，并将其与正常对照进行比较。我们的研究结果表明，V1 LPZ的边界保持稳定，这表明MD动物的缺齿区域V1区的重组能力有限。有趣的是，未脱除咖啡因的V1体素的pRF大小略有增加（平均约20％），尽管这种作用似乎比以前的单单位记录报告要弱。 V2区也显示出有限的重组。值得注意的是，与在MD动物中幸存的部分视野刺激相比，MD动物的V5 / MT区域显示出广泛的激活作用。此外，在MD动物的V5 / MT区域中，群体接受区域的大小分布明显不同。综上所述，这些结果表明，与早期的视觉皮层相比，V5 / MT在MD后具有更高的重组潜力。

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