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首页> 外文期刊>The European Journal of Neuroscience >The effect of auditory cortex deactivation on stimulus-specific adaptation in the inferior colliculus of the rat
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The effect of auditory cortex deactivation on stimulus-specific adaptation in the inferior colliculus of the rat

机译：听性皮层失活对大鼠下丘脑刺激特异性适应的影响

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Many neurons in the central auditory pathway, from the inferior colliculus (IC) to the auditory cortex (AC), respond less strongly to a commonly occurring stimulus than one that rarely occurs. The origin of this phenomenon, called stimulus-specific adaptation (SSA), remains uncertain. The AC sends descending projections to the IC that terminate most densely upon the dorsal, lateral and rostral IC cortices - areas where strong SSA has been reported. To investigate whether SSA in the IC is dependent upon the AC for its generation, we recorded the response from single IC neurons to stimuli presented in an oddball paradigm before, during and after reversibly deactivating the ipsilateral AC with a cryoloop. While changes in the basic response properties of the IC neurons were widespread (89%), changes in SSA sensitivity were less common; approximately half of the neurons recorded showed a significant change in SSA, while the other half remained unchanged. Changes in SSA could be in either direction: 18% enhanced their SSA sensitivity, while 34% showed reduced SSA sensitivity. For the majority of this latter group, cortical deactivation reduced, but did not eliminate, significant SSA levels. Only eight neurons seemed to inherit SSA from the AC, as their pre-existing significant level of SSA became non-significant during cortical deactivation. Thus, the presence of SSA in the IC is generally not dependent upon the corticocollicular projection, suggesting the AC is not essential for the generation of subcortical SSA; however, the AC may play a role in the modulation of subcortical SSA.
机译：从下丘脑（IC）到听觉皮层（AC）的中央听觉通路中的许多神经元对一种常见刺激的反应较不常见。这种现象的起源，称为刺激特异性适应（SSA），仍然不确定。 AC向IC发送下降的投影，这些投影最密集地终止于IC的背侧，侧面和头侧皮质（据报道有强烈的SSA的区域）。为了研究IC中的SSA是否依赖于AC的生成，我们记录了单个IC神经元对用冷冻回路可逆性停用同侧AC之前，期间和之后对奇异球范例中呈现的刺激的反应。尽管IC神经元的基本反应特性发生了广泛的变化（89％），但SSA敏感性的变化却并不常见。记录的大约一半神经元显示SSA有显着变化，而另一半则保持不变。 SSA的变化可能是双向的：18％的SSA敏感性提高，而34％的SSA敏感性降低。对于后一组中的大多数，皮质失活可减少但不能消除明显的SSA水平。似乎只有八个神经元从AC继承了SSA，因为它们先前存在的重要SSA水平在皮层失活期间变得不再重要。因此，IC中SSA的存在通常不依赖于皮质胶体投影，这表明AC对于皮层下SSA的产生不是必不可少的。但是，AC可能在皮层下SSA的调制中起作用。

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