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首页> 外文期刊>The European Journal of Neuroscience >Rapid dopamine transmission within the nucleus accumbens: Dramatic difference between morphine and oxycodone delivery
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Rapid dopamine transmission within the nucleus accumbens: Dramatic difference between morphine and oxycodone delivery

机译：多巴胺在伏隔核内的快速传播：吗啡和羟考酮的递送之间存在巨大差异

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摘要

While most drugs of abuse increase dopamine neurotransmission, rapid neurochemical measurements show that different drugs evoke distinct dopamine release patterns within the nucleus accumbens. Rapid changes in dopamine concentration following psychostimulant administration have been well studied; however, such changes have never been examined following opioid delivery. Here, we provide novel measures of rapid dopamine release following intravenous infusion of two opioids, morphine and oxycodone, in drug-na?ve rats using fast-scan cyclic voltammetry and rapid (1 min) microdialysis coupled with high-performance liquid chromatography - tandem mass spectrometry (HPLC-MS). In addition to measuring rapid dopamine transmission, microdialysis HPLC-MS measures changes in GABA, glutamate, monoamines, monoamine metabolites and several other neurotransmitters. Although both opioids increased dopamine release in the nucleus accumbens, their patterns of drug-evoked dopamine transmission differed dramatically. Oxycodone evoked a robust and stable increase in dopamine concentration and a robust increase in the frequency and amplitude of phasic dopamine release events. Conversely, morphine evoked a brief (~ 1 min) increase in dopamine that was coincident with a surge in GABA concentration and then both transmitters returned to baseline levels. Thus, by providing rapid measures of neurotransmission, this study reveals previously unknown differences in opioid-induced neurotransmitter signaling. Investigating these differences may be essential for understanding how these two drugs of abuse could differentially usurp motivational circuitry and powerfully influence behavior.
机译：虽然大多数滥用药物会增加多巴胺的神经传递，但快速的神经化学测量表明，不同的药物会引起伏伏核内不同的多巴胺释放模式。服用精神兴奋药后多巴胺浓度的快速变化已得到很好的研究。然而，这种变化从未在阿片类药物给药后被检查过。在这里，我们提供了使用快速扫描循环伏安法和快速（1分钟）微透析与高效液相色谱-串联技术在未使用过药物的大鼠中静脉输注两种阿片类药物吗啡和羟考酮后多巴胺快速释放的新方法。质谱（HPLC-MS）。除了测量多巴胺的快速传递外，微透析HPLC-MS还可以测量GABA，谷氨酸，单胺，单胺代谢产物和其他几种神经递质的变化。尽管两种阿片类药物均增加伏隔核中多巴胺的释放，但它们引起的药物诱发的多巴胺传递的方式却截然不同。羟考酮引起了多巴胺浓度的强劲而稳定的增加，以及多巴胺释放事件的频率和幅度的强劲增加。相反，吗啡引起多巴胺的短暂增加（〜1分钟），这与GABA浓度的上升同时发生，然后两个递质恢复到基线水平。因此，通过提供神经传递的快速测量，该研究揭示了阿片样物质诱导的神经递质信号传导中以前未知的差异。研究这些差异对于理解这两种滥用药物如何能够有区别地篡改动机回路并强烈影响行为至关重要。

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