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首页> 外文期刊>The European Journal of Neuroscience >Selective modulation of motor cortical plasticity during voluntary contraction of the antagonist muscle
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Selective modulation of motor cortical plasticity during voluntary contraction of the antagonist muscle

机译：拮抗肌自愿收缩期间运动皮质可塑性的选择性调节

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摘要

A fundamental approach for resolving motor deficits in patients suffering from various neurological diseases is to improve the impaired cortical function through the modulation of plasticity. In order to advance clinical practice in this regard, it is necessary to better understand the interactions that occur between functional neuromuscular activity and the resulting cortical plasticity. This study tested whether the voluntary contraction of an antagonist muscle modulates the plasticity-like effect of continuous theta burst stimulation (cTBS) recorded from the agonist. The effects of various opposing torques produced by the antagonist were also measured. As a result, the suppressing effect of cTBS was enhanced by mild antagonist contraction, whereas effortful antagonist contraction suspended the plasticity caused by cTBS. In contrast, the antagonist contractions right after cTBS did not significantly influence the effect of cTBS. The results indicate that the antagonist activity alters the effect of cTBS, especially in protocols with synchronous magnetic stimulation and antagonist contraction. Such modulation on cTBS may be through a reciprocal mechanism within the motor cortex, although the spinal regulation of the motoneuronal pool cannot be fully excluded. The present findings are beneficial for elucidating the mechanism of neuromuscular control and for resolving related neurological disorders.
机译：解决患有各种神经系统疾病的患者运动功能障碍的基本方法是通过调节可塑性来改善受损的皮层功能。为了在这方面推进临床实践，有必要更好地了解功能性神经肌肉活动与所产生的皮质可塑性之间的相互作用。这项研究测试了拮抗肌的自愿收缩是否调节了激动剂记录的连续θ爆裂刺激（cTBS）的可塑性样效果。还测量了拮抗剂产生的各种相反转矩的作用。结果，轻度的拮抗剂收缩增强了cTBS的抑制作用，而费力的拮抗剂收缩则暂停了cTBS引起的可塑性。相反，cTBS之后的拮抗剂收缩对cTBS的作用没有明显影响。结果表明，拮抗剂的活性改变了cTBS的作用，特别是在同步磁刺激和拮抗剂收缩的方案中。尽管无法完全排除运动神经元池的脊柱调节，但对cTBS的这种调节可能是通过运动皮层内的相互作用机制实现的。目前的发现对于阐明神经肌肉控制的机制和解决相关的神经系统疾病是有益的。

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