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首页> 外文期刊>The European Journal of Neuroscience >The role of pedunculopontine nucleus in choice behavior under risk
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The role of pedunculopontine nucleus in choice behavior under risk

机译：足小脑桥骨核在高危人群选择行为中的作用

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The dopaminergic projections to the basal ganglia have long been implicated in reward-guided behavior and decision-making, yet little is known about the role of the posterior pedunculopontine nucleus (pPPN), a major source of excitatory input to the mesolimbic dopamine system. Here we studied the contributions of the pPPN to decision-making under risk, using excitoxic lesions and reversible inactivation in rats. Rats could choose between two options - a small but certain reward on one lever; or a large but uncertain reward on the other lever. The overall payoff associated with each choice is the same, but the reward variance (risk) associated with the risky choice is much higher. In Experiment 1, we showed that excitotoxic lesions of the pPPN before training did not affect acquisition of lever pressing. But whereas the controls strongly preferred the safe choice, the lesioned rats did not. In Experiment 2, we found that muscimol inactivation of the pPPN also produced similar effects, but reversibly. These results show that permanent lesions or reversible inactivation of the pPPN both abolish risk aversion in decision-making.
机译：对基底神经节的多巴胺能投射长期以来一直与奖励指导的行为和决策有关，但对后足桥神经元核（pPPN）（中脑边缘多巴胺系统兴奋性输入的主要来源）的作用知之甚少。在这里，我们研究了pPPN在高危条件下使用兴奋毒性损害和大鼠可逆失活对决策的贡献。老鼠可以在两种选择之间进行选择-在一个杠杆上获得少量但一定的回报;或在另一个杠杆上获得丰厚但不确定的回报。与每个选择相关的总收益是相同的，但是与风险选择相关的奖励方差（风险）要高得多。在实验1中，我们证明了训练前pPPN的兴奋性毒性损害并不影响杠杆按压的获得。但是，尽管对照组强烈选择安全的选择，但病变大鼠却没有这样做。在实验2中，我们发现pPPN的麝香酚灭活也产生了相似的作用，但可逆地发生。这些结果表明，永久性病变或pPPN的可逆失活都消除了决策中的风险规避。

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