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首页> 外文期刊>The European Journal of Neuroscience >Unilateral striatal dopamine depletion: time-dependent effects on cortical function and behavioural correlates.
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Unilateral striatal dopamine depletion: time-dependent effects on cortical function and behavioural correlates.

机译：单侧纹状体多巴胺耗竭：对皮质功能和行为相关性的时间依赖性影响。

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Previously, we showed that unilateral blockade of D1 dopamine receptors in the striatum inhibits immediate-early gene expression bilaterally throughout large parts of the cortex, including sensory-evoked expression in the barrel cortex. To further investigate this dopamine regulation of cortical function, we examined the effects of dopamine depletion on cortical gene regulation and behavioural correlates. Two days after unilateral infusion of 6-hydroxydopamine into the midbrain, rats displayed a (to some degree) bilateral reduction in cortical zif 268 expression that was more pronounced on the lesioned side. This decrease was found across motor, somatosensory, insular and piriform, but not cingulate, cortex, similar to the effects of blockade of striatal D1 receptors. Furthermore, whisker stimulation-evoked c-fos and zif 268 expression in the barrel cortex ipsilateral to the lesion was also attenuated by acute dopamine depletion. These cortical deficits were accompanied by a breakdown of spontaneous behaviours in an open-field test. In contrast, 21 days after dopamine depletion, both basal and sensory-evoked gene expression in the cortex were near-normal. This cortical recovery was paralleled by recovery in locomotion and in sensory-guided behaviour (scanning) related to the hemisphere contralateral to the lesion, but not in scanning by the dopamine-depleted hemisphere. Our results suggest that striatal dopamine exerts a widespread facilitatory influence on cortical function that is necessary, but not sufficient, for normal behaviour. Moreover, the mechanisms mediating this cortical facilitation appear to be subject to substantial neuroplasticity after dopamine perturbation.
机译：以前，我们表明纹状体中D1多巴胺受体的单方面阻断会在整个皮质大部分区域中双向抑制即刻早期基因表达，包括在桶状皮质中诱发感觉表达。为了进一步研究这种皮质功能的多巴胺调节，我们研究了多巴胺耗竭对皮质基因调节和行为相关性的影响。在单侧将6-羟基多巴胺输注到中脑两天后，大鼠的皮质zif 268表达在一定程度上双侧降低（在某种程度上），在病变侧更为明显。在运动，体感，岛状和梨状但不是扣带状的皮层中发现了这种减少，类似于纹状体D1受体的阻断作用。此外，急性多巴胺耗竭也减弱了晶须刺激诱发的c-fos和zif 268在病变同侧桶状皮质中的表达。在开放视野测试中，这些皮质功能障碍伴有自发性行为的崩溃。相反，多巴胺耗竭后21天，皮层的基础和感觉诱发基因表达均接近正常。这种皮层的恢复与运动和与病变对侧的半球相关的感觉引导行为（扫描）的恢复相平行，而与多巴胺耗尽的半球的扫描不相伴。我们的结果表明，纹状体多巴胺对皮质功能具有广泛的促进作用，这对于正常行为而言是必要的，但并不充分。此外，在多巴胺摄动后，介导这种皮质促进作用的机制似乎具有实质性的神经可塑性。

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