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首页> 外文期刊>The European Journal of Neuroscience >Differential daily expression of Per1 and Per2 mRNA in the suprachiasmatic nucleus of fetal and early postnatal mice.
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Differential daily expression of Per1 and Per2 mRNA in the suprachiasmatic nucleus of fetal and early postnatal mice.

机译：胎鼠和产后早期小鼠视交叉上核中Per1和Per2 mRNA的每日差异表达。

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摘要

It is well known that there are circadian rhythms of 2-deoxyglucose uptake and neuronal firing in the rat suprachiasmatic nucleus (SCN) during fetal and early postnatal periods. A core clock mechanism in the mouse SCN appears to involve a transcriptional feedback loop in which CLOCK and BMAL1 function as positive regulators and three mPeriod (mPer) genes play a role in negative feedback. Per genes expression occurs not only in the adult SCN but also in the fetal SCN. However, the developmental change in these genes remains unclear. In this experiment, we examined the day--night pattern of expression of Per1 and Per2 mRNA in the mouse SCN and cerebral cortex on embryonic day 17, postnatal day 3, and in young adult mice under a light-dark cycle. Daily rhythms of mRNA content were observed in mPer1 but not mPer2 in the fetal SCN. Interestingly, the expression of mPer2 in the SCN was high throughout the entire day, and a significant daily rhythm of this gene was observed on postnatal day 6. The expression pattern of SCN mPer1 in constant darkness was similar to that seen in the light-dark cycle. The present results suggest that the daily oscillation of mPer1 but not of mPer2 in the SCN in fetal and early postnatal mice may be associated with the daily rhythms of 2-deoxyglucose uptake and neuronal firing.
机译：众所周知，在胎儿和出生后早期，大鼠视交叉上核（SCN）中存在2-脱氧葡萄糖摄取和神经元放电的昼夜节律。小鼠SCN中的核心时钟机制似乎涉及转录反馈环，其中CLOCK和BMAL1充当正调节剂，三个mPeriod（mPer）基因在负反馈中起作用。每个基因的表达不仅在成人SCN中发生，而且在胎儿SCN中也发生。但是，这些基因的发育变化仍不清楚。在此实验中，我们检查了小鼠SCN和大脑皮层在胚胎第17天，出生后第3天以及成年小鼠在明暗周期下Per1和Per2 mRNA的昼夜表达模式。在胎儿SCN中观察到mPer1的每日节律性，但在mPer2中未观察到。有趣的是，SCN中mPer2的表达在整天中都很高，并且在出生后的第6天观察到了该基因的明显每日节律。在持续黑暗中，SCN mPer1的表达模式与在黑暗中相似。周期。目前的结果表明，胎儿和早期产后小鼠的SCN中mPer1的每日振荡而不是mPer2的每日振荡可能与2-脱氧葡萄糖摄取和神经元放电的每日节律有关。

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