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首页> 外文期刊>The European Journal of Neuroscience >Network mechanisms of responsiveness to continuous theta-burst stimulation
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Network mechanisms of responsiveness to continuous theta-burst stimulation

机译：对持续的θ-爆发刺激反应的网络机制

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Continuous theta-burst stimulation (cTBS) can modify behavior, but effects are inconsistent and their mechanisms insufficiently understood. As coherence in resting-state networks influences human behavior, we hypothesized that cTBS may act via modulation of neural oscillation coherence. This study used electroencephalography (EEG) to investigate whether behavioral effects of cTBS on visuospatial attention are associated with coherence changes in the attention network. In healthy human subjects, cTBS of the right posterior parietal cortex (PPC) and the right frontal eye field was compared with sham stimulation. Effects on visuospatial attention were quantified with a visual exploration task, and network effects were assessed from surface EEG with inverse solutions and source coherence analyses. Before stimulation, left visual exploration was linearly correlated with alpha-band coherence between the right temporo-parietal cortex and the rest of the brain. Posterior parietal cortex stimulation induced neglect-like visual exploration behavior in the majority, but not all, subjects. It reduced alpha-band coherence between the stimulation site and the rest of the brain but also enhanced it between the contralateral left parietal cortex and the rest of the brain. The contralateral increase correlated with the induced reduction in left visual attention. The behavioral response of individual participants to cTBS could be predicted by coherence in the right temporo-parietal junction before stimulation. Behavioral effects of cTBS therefore depend on network states before stimulation and are linearly associated with changes in network interactions. In particular, cTBS modulates an interhemispheric competition in alpha-band coherence. EEG network imaging might help to optimize therapeutic cTBS in the future.
机译：持续的Theta-burst刺激（cTBS）可以改变行为，但是效果不一致，并且对其机理还缺乏了解。由于静止状态网络中的相干性会影响人类行为，因此我们假设cTBS可能通过调节神经振荡相干性来发挥作用。这项研究使用脑电图（EEG）来研究cTBS对视觉空间注意力的行为影响是否与注意力网络的连贯性变化相关。在健康人类受试者中，将右后顶叶皮层（PPC）和右额眼视野的cTBS与假刺激相比较。通过视觉探索任务量化对视觉空间注意力的影响，并通过反演和源一致性分析从表面脑电图评估网络效应。在刺激之前，左视探查与右颞顶叶皮层和大脑其他部位之间的α波段相关性线性相关。后顶叶皮层刺激在大多数（但不是全部）受试者中引起了类似忽视的视觉探索行为。它降低了刺激部位与大脑其余部位之间的α波段一致性，但也增强了对侧左顶叶皮层与大脑其余部位之间的α波段一致性。对侧增加与诱导的左视力下降相关。个体参与者对cTBS的行为反应可以通过刺激前右侧颞顶交界处的连贯性来预测。因此，cTBS的行为效应取决于刺激之前的网络状态，并且与网络交互作用的变化线性相关。尤其是，cTBS调节了alpha波段相干性的半球竞争。脑电网络成像可能会有助于将来优化治疗性cTBS。

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