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首页> 外文期刊>The European Journal of Neuroscience >Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities.
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Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities.

机译：大鼠的细胞外hypocretin-1（orexin A）水平的波动与明暗周期和睡眠觉醒活动有关。

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摘要

Hypocretins/orexins are neuropeptides implicated in sleep regulation and the sleep disorder narcolepsy. In order to examine how hypocretin activity fluctuates across 24 h with respect to the sleep-wake cycle, we measured changes in extracellular hypocretin-1 levels in the lateral hypothalamus and medial thalamus of freely moving rats with simultaneous sleep recordings. Hypocretin levels exhibited a robust diurnal fluctuation; levels slowly increased during the dark period (active phase), and decreased during the light period (rest phase). Levels were not correlated with the amount of wake or sleep in each period. Although an acute 4-h light-shift did not alter hypocretin levels, 6-h sleep deprivation significantly increased hypocretin release during the forced-wake period. Hypocretin activity is, thus, likely to build up during wakefulness and decline with the occurrence of sleep. These findings, together with the fact that a difficulty in maintaining wakefulness during the daytime is one of the primary symptoms of hypocretin-deficient narcolepsy, suggest that hypocretin activity may be critical in opposing sleep propensity during periods of prolonged wakefulness.
机译：降钙素/食欲激素是与睡眠调节和睡眠障碍性发作性睡病有关的神经肽。为了检查降钙素活性相对于睡眠-觉醒周期如何在24小时内波动，我们测量了自由活动大鼠的下丘脑外侧和内侧丘脑中细胞外hypocretin-1水平的变化，同时记录了睡眠。降钙素水平表现出强烈的昼夜波动;在黑暗时期（活跃阶段），其水平缓慢增加，在黑暗时期（休息阶段），其水平逐渐降低。水平与每个时期的唤醒或睡眠量均不相关。尽管急性的4小时轻度移位不会改变降钙素的水平，但是在强迫醒期间6小时的睡眠剥夺显着增加了降钙素的释放。因此，降钙素活性可能会在清醒时增加，并随着睡眠的发生而下降。这些发现以及白天难以保持清醒是降钙素缺乏的发作性睡病的主要症状之一这一事实表明，降钙素活动可能在长时间的清醒期间对抗睡眠倾向至关重要。

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