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首页> 外文期刊>The European Journal of Neuroscience >Lesions to the CA2 region of the hippocampus impair social memory in mice
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Lesions to the CA2 region of the hippocampus impair social memory in mice

机译：海马CA2区病变损害小鼠社交记忆

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The function of the CA2 region of the hippocampus is poorly understood. Although the CA1 and CA3 regions have been extensively studied, for years the CA2 region has primarily been viewed as a linking area between the two. However, the CA2 region is known to have distinct neurochemical and structural features that are different from the other parts of the hippocampus and in recent years it has been suggested that the CA2 region may play a role in the formation and/or recall of olfactory-based memories needed for normal social behavior. Although this hypothesis has been supported by hippocampal lesion studies that have included the CA2 region, no studies have attempted to specifically lesion the CA2 region of the hippocampus in mice to determine the effects on social recognition memory and olfaction. To fill this knowledge gap, we sought to perform excitotoxic N-methyl-D-aspartate lesions of the CA2 region and determine the effects on social recognition memory. We predicted that lesions of the CA2 region would impair social recognition memory. We then went on to test olfaction in CA2-lesioned mice, as social memory requires a functional olfactory system. Consistent with our prediction, we found that CA2-lesioned animals had impaired social recognition. These findings are significant because they confirmed that the CA2 region of the hippocampus is a part of the neural circuitry that regulates social recognition memory, which may have implications for our understanding of the neural regulation of social behavior across species.
机译：海马CA2区的功能了解甚少。尽管对CA1和CA3区域进行了广泛的研究，但多年来，CA2区域主要被视为两者之间的链接区域。然而，众所周知，CA2区具有不同于海马其他部位的独特神经化学和结构特征，近年来，有人提出CA2区可能在嗅觉形成和/或召回中发挥作用。正常社交行为所需的基础记忆。尽管这一假说得到了包括CA2区域在内的海马病变研究的支持，但是还没有研究试图对小鼠海马CA2区域进行特异性病变以确定对社会认知记忆和嗅觉的影响。为了填补这一知识空白，我们寻求对CA2区进行兴奋性N-甲基-D-天冬氨酸损伤，并确定对社会认知记忆的影响。我们预测，CA2区的病变会损害社会认知记忆。然后，我们继续在CA2病变小鼠中测试嗅觉，因为社交记忆需要功能性嗅觉系统。与我们的预测一致，我们发现患有CA2的动物损害了社会认可度。这些发现具有重要意义，因为它们证实了海马的CA2区是调节社交识别记忆的神经回路的一部分，这可能对我们理解跨物种的社交行为的神经调节有影响。

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