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首页> 外文期刊>The European Journal of Neuroscience >Prelimbic and infralimbic cortical regions differentially encode cocaine-associated stimuli and cocaine-seeking before and following abstinence
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Prelimbic and infralimbic cortical regions differentially encode cocaine-associated stimuli and cocaine-seeking before and following abstinence

机译：禁欲前后，皮层前缘和下缘皮层区不同地编码可卡因相关刺激和可卡因寻找

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摘要

Cocaine stimuli often trigger relapse of drug-taking, even following periods of prolonged abstinence. Here, electrophysiological recordings were made in rats (n = 29) to determine how neurons in the prelimbic (PrL) or infralimbic (IL) regions of the medial prefrontal cortex (mPFC) encode cocaine-associated stimuli and cocaine-seeking, and whether this processing is differentially altered after 1 month of cocaine abstinence. After self-administration training, neurons (n = 308) in the mPFC were recorded during a single test session conducted either the next day or 1 month later. Test sessions consisted of three phases during which (i) the tone-houselight stimulus previously paired with cocaine infusion during self-administration was randomly presented by the experimenter, (ii) rats responded on the lever previously associated with cocaine during extinction and (iii) the tone-houselight was presented randomly between cocaine-reinforced responding during resumption of cocaine self-administration. PrL neurons showed enhanced encoding of the cocaine stimulus and drug-seeking behavior (under extinction and self-administration) following 30 days of abstinence. In contrast, although IL neurons encoded cocaine cues and cocaine-seeking, there were no pronounced changes in IL responsiveness following 30 days of abstinence. Importantly, cue-related changes do not represent a generalised stimulus-evoked discharge as PrL and IL neurons in control animals (n = 4) exhibited negligible recruitment by the tone-houselight stimulus. The results support the view that, following abstinence, neural encoding in the PrL but not IL may play a key role in enhanced cocaine-seeking, particularly following re-exposure to cocaine-associated cues.
机译：可卡因刺激通常会导致药物滥用的复发，即使在长期禁欲之后也是如此。在这里，在大鼠（n = 29）中进行了电生理记录，以确定内侧前额叶皮层（mPFC）的前缘（PrL）或下缘（IL）区域中的神经元如何编码可卡因相关的刺激和可卡因的寻找，以及这是否可卡因戒断1个月后，其加工过程有所不同。在自我管理培训之后，第二天或1个月后进行的一次测试中记录了mPFC中的神经元（n = 308）。测试阶段包括三个阶段，其中（i）实验者随机提出先前在自我给药过程中与可卡因输注配合使用的调性光刺激，（ii）大鼠在灭绝过程中对先前与可卡因有关的杠杆产生反应，并且（iii）恢复可卡因自我管理期间，可卡因增强的反应之间随机出现了调性光。禁欲30天后，PrL神经元显示出增强的可卡因刺激编码和药物寻求行为（在灭绝和自我给药下）。相比之下，尽管IL神经元编码可卡因提示和可卡因寻找，但禁欲30天后IL反应性没有明显变化。重要的是，与提示相关的变化并不代表普遍的刺激诱发放电，因为对照动物（n = 4）中的PrL和IL神经元通过室内光照刺激表现出可忽略的募集。结果支持以下观点：禁欲后，PrL中的神经编码而非IL中的神经编码可能在增强可卡因寻找中起关键作用，尤其是在再次暴露于可卡因相关提示后。

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