...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Nucleus accumbens shell and core dopamine responsiveness to sucrose in rats: role of response contingency and discriminative/conditioned cues
【24h】

Nucleus accumbens shell and core dopamine responsiveness to sucrose in rats: role of response contingency and discriminative/conditioned cues

机译：伏伏核壳和核心多巴胺对大鼠蔗糖的反应性：反应性偶然性和区分性/条件性线索的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study investigated by microdialysis the role of response contingency and food-associated cues in the responsiveness of dopamine transmission in the nucleus accumbens shell and core to sucrose feeding. In naive rats, single-trial non-contingent presentation and feeding of sucrose pellets increased dialysate shell dopamine and induced full habituation of dopamine responsiveness to sucrose feeding 24 and 48h later. In rats trained to respond for sucrose pellets on a fixed ratio 1 (FR1) schedule, dialysate dopamine increased in the shell but not in the core during active responding as well as under extinction in the presence of sucrose cues. In rats yoked to the operant rats, the presentation of sucrose cues also increased dialysate dopamine selectively in the shell. In contrast, non-contingent sucrose presentation and feeding in FR1-trained and in yoked rats increased dialysate dopamine to a similar extent in the shell and core. It is concluded that, whereas non-contingent sucrose feeding activated dopamine transmission in the shell and core, response-contingent feeding activated, without habituation, dopamine transmission selectively in the shell as a result of the action of sucrose conditioned cues. These observations are consistent with a critical role of conditioned cues acquired during training and differential activation of shell vs. core dopamine for response-contingent sucrose feeding.
机译：这项研究通过微透析研究了反应偶然性和食物相关线索在伏伏核壳和核中多巴胺传递对蔗糖摄食的响应中的作用。在幼稚大鼠中，单次试验非偶然性提供和饲喂蔗糖颗粒增加了透析液壳多巴胺的含量，并诱导了多巴胺对蔗糖饲喂24和48小时后的反应的完全适应。在训练为以固定比率1（FR1）时间表对蔗糖小球做出反应的大鼠中，在主动反应期间以及在存在蔗糖提示的情况下灭绝的情况下，透析液中的多巴胺在壳中增加，但在核心中不增加。在与手术大鼠轭在一起的大鼠中，蔗糖提示的出现还选择性地增加了壳中的透析液多巴胺。相比之下，非偶然性蔗糖的呈递和在FR1训练的和轭铁大鼠中的摄食增加了壳和核中的透析液多巴胺的含量。结论是，尽管非偶然性蔗糖进食激活了壳和核中的多巴胺传递，但响应性偶然性进食却没有习惯性地激活了，由于蔗糖条件提示的作用，多巴胺在壳中选择性地传递。这些观察结果与在训练期间获得的条件提示的关键作用以及壳对核心多巴胺的差异激活用于反应性蔗糖进料的关键作用相一致。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号