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首页> 外文期刊>The European Journal of Neuroscience >Interaction of synchronized dynamics in cortex and basal ganglia in Parkinson's disease
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Interaction of synchronized dynamics in cortex and basal ganglia in Parkinson's disease

机译：帕金森病皮层和基底神经节同步动力学的相互作用

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Parkinson's disease pathophysiology is marked by increased oscillatory and synchronous activity in the beta frequency band in cortical and basal ganglia circuits. This study explores the functional connections between synchronized dynamics of cortical areas and synchronized dynamics of subcortical areas in Parkinson's disease. We simultaneously recorded neuronal units (spikes) and local field potentials (LFP) from subthalamic nucleus (STN) and electroencephalograms (EEGs) from the scalp in parkinsonian patients, and analysed the correlation between the time courses of the spike-LFP synchronization and inter-electrode EEG synchronization. We found the (non-invasively obtained) time course of the synchrony strength between EEG electrodes and the (invasively obtained) time course of the synchrony between spiking units and LFP in STN to be weakly, but significantly, correlated with each other. This correlation is largest for the bilateral motor EEG synchronization, followed by bilateral frontal EEG synchronization. Our observations suggest that there may be multiple functional modes by which the cortical and basal ganglia circuits interact with each other in Parkinson's disease: not only may synchronization be observed between some areas in cortex and the basal ganglia, but also synchronization within cortex and within basal ganglia may be related, suggesting potentially a more global functional interaction. More coherent dynamics in one brain region may modulate or activate the dynamics of another brain region in a more powerful way, causing correlations between changes in synchrony strength in the two regions.
机译：帕金森氏病的病理生理学特征是皮质和基底神经节回路中β频段的振荡和同步活动增加。这项研究探讨了帕金森氏病的皮质区域同步动态与皮质下区域同步动态之间的功能联系。我们同时记录了帕金森病患者的丘脑下丘脑核（STN）和脑电图（EEGs）的神经元单位（峰值）和局部场电位（LFP），并分析了峰值LFP同步和相互之间的时间过程之间的相关性。电极脑电图同步。我们发现，STN中脑电图电极之间同步强度的（非侵入性获得）时间进程和突波单元与LFP之间同步的（侵入性获得）时间进程之间存在较弱但显着的相关性。对于双边运动EEG同步，此相关性最大，其次是双边额叶EEG同步。我们的观察结果表明，在帕金森氏病中，可能存在多种功能模式，皮质和基底神经节回路彼此相互作用：不仅在皮质和基底神经节的某些区域之间可以观察到同步，而且在皮质内和基底内也可以观察到同步。神经节可能相关，表明潜在的更广泛的功能相互作用。一个大脑区域中更连贯的动态可能会以更强大的方式调节或激活另一个大脑区域的动态，从而导致两个区域的同步强度变化之间存在相关性。

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