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首页> 外文期刊>The European Journal of Neuroscience >Anesthetic effects of isoflurane on the tonotopic map and neuronal population activity in the rat auditory cortex
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Anesthetic effects of isoflurane on the tonotopic map and neuronal population activity in the rat auditory cortex

机译：异氟醚对大鼠听皮层局部分布图和神经元种群活动的麻醉作用。

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Since its discovery nearly four decades ago, sequential microelectrode mapping using hundreds of recording sites has been able to reveal a precise tonotopic organization of the auditory cortex. Despite concerns regarding the effects that anesthesia might have on neuronal responses to tones, anesthesia was essential for these experiments because such dense mapping was elaborate and time-consuming. Here, taking an 'all-at-once' approach, we investigated how isoflurane modifies spatiotemporal activities by using a dense microelectrode array. The array covered the entire auditory cortex in rats, including the core and belt cortices. By comparing neuronal activity in the awake state with activity under isoflurane anesthesia, we made four observations. First, isoflurane anesthesia did not modify the tonotopic topography within the auditory cortex. Second, in terms of general response properties, isoflurane anesthesia decreased the number of active single units and increased their response onset latency. Third, in terms of tuning properties, isoflurane anesthesia shifted the response threshold without changing the shape of the frequency response area and decreased the response quality. Fourth, in terms of population activities, isoflurane anesthesia increased the noise correlations in discharges and phase synchrony in local field potential (LFP) oscillations, suggesting that the anesthesia made neuronal activities redundant at both single-unit and LFP levels. Thus, while isoflurane anesthesia had little effect on the tonotopic topography, its profound effects on neuronal activities decreased the encoding capacity of the auditory cortex.
机译：自将近40年前发现以来，使用数百个记录位点进行的连续微电极作图已经能够揭示出听觉皮层的精确异位组织。尽管担心麻醉可能会对神经元对音调的反应产生影响，但是麻醉对于这些实验至关重要，因为这种密集的映射非常复杂且耗时。在这里，我们采用“一次全部”的方法，研究了异氟烷如何通过使用致密的微电极阵列来修饰时空活动。该阵列覆盖了大鼠的整个听觉皮层，包括核心和带状皮层。通过比较清醒状态下的神经元活性与异氟烷麻醉下的神经元活性，我们做了四个观察。首先，异氟烷麻醉并不能改变听觉皮层内的正畸形地形。其次，就一般反应特性而言，异氟烷麻醉减少了活动单个单元的数量，并增加了它们的反应发作潜伏期。第三，就调谐特性而言，异氟醚麻醉可改变响应阈值，而不会改变频率响应区域的形状并降低响应质量。第四，就种群活动而言，异氟醚麻醉增加了放电的噪声相关性，并增加了局部场电位（LFP）振荡的相位同步，这表明麻醉使神经元活动在单单位水平和LFP水平上都是多余的。因此，尽管异氟烷麻醉对tonotopic地形影响不大，但其对神经元活动的深刻影响降低了听觉皮层的编码能力。

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