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首页> 外文期刊>The European Journal of Neuroscience >Sustained activation of GABAa receptors in the suprachiasmatic nucleus mediates light-induced phase delays of the circadian clock: a novel function of ionotropic receptors
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Sustained activation of GABAa receptors in the suprachiasmatic nucleus mediates light-induced phase delays of the circadian clock: a novel function of ionotropic receptors

机译：视交叉上核中GABA a受体的持续激活介导了昼夜节律光诱导的相位延迟：离子受体的新功能

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摘要

The suprachiasmatic nucleus (SCN) contains a circadian clock that generates endogenous rhythmicity and entrains that rhythmic-ity with the day-night cycle. The neurochemical events that transduce photic input within the SCN and mediate entrainment by resetting the molecular clock have yet to be defined. Because GABA is contained in nearly all SCN neurons we tested the hypothesis that GABA serves as this signal in studies employing Syrian hamsters (Mesocricetus auratus). Activation of GABAA receptors was found to be necessary and sufficient for light to induce phase delays of the clock. Remarkably, the sustained activation of GABAA receptors for more than three consecutive hours was necessary to phase-delay the clock. The duration of GABAA receptor activation required to induce phase delays would not have been predicted by either the prevalent theory of circadian entrainment or by expectations regarding the duration of ionotropic receptor activation necessary to produce functional responses. Taken together, these data identify a novel neurochemical mechanism essential for phase-delaying the 'master' circadian clock within the SCN as well as identifying an unprecedented action of an amino acid neurotransmitter involving the sustained activation of ionotropic receptors.
机译：视交叉上核（SCN）包含一个昼夜节律时钟，该时钟产生内源性节律并伴随昼夜循环带动节律。在SCN中转导光输入并通过重置分子钟来介导夹带的神经化学事件尚未确定。由于GABA几乎包含在所有SCN神经元中，因此我们在使用叙利亚仓鼠（Mesocricetus auratus）的研究中检验了GABA充当该信号的假设。发现GABA A受体的激活对于光引起时钟的相位延迟是必要的和充分的。值得注意的是，必须连续三个小时以上持续激活GABAA受体才能使时钟相位延迟。昼夜夹带的流行理论或对产生功能性反应所必需的离子性受体激活持续时间的预期都无法预测诱导相位延迟所需的GABA A受体激活持续时间。综上所述，这些数据确定了一种新的神经化学机制，该机制对于SCN内“主”生物钟的相位延迟必不可少，还可以识别涉及离子活性受体持续激活的氨基酸神经递质的空前作用。

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