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首页> 外文期刊>The European Journal of Neuroscience >Dopamine physiology in the basal ganglia of male zebra finches during social stimulation
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Dopamine physiology in the basal ganglia of male zebra finches during social stimulation

机译：社会刺激过程中雄性斑马雀的基底神经节中的多巴胺生理

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Accumulating evidence suggests that dopamine (DA) is involved in altering neural activity and gene expression in a zebra finch cortical-basal ganglia circuit specialized for singing, upon the shift between solitary singing and singing as a part of courtship. Our objective here was to sample changes in the extracellular concentrations of DA in Area X of adult and juvenile birds, to test the hypothesis that DA levels would change similarly during presentation of a socially salient stimulus in both age groups. We used microdialysis to sample the extracellular milieu of Area X in awake, behaving adult and juvenile male zebra finches, and analysed the dialysate using high-performance liquid chromatography coupled with electrochemical detection. The extracellular levels of DA in Area X increased significantly during both female presentation to adult males and tutor presentation to juvenile males. DA levels were not correlated with the time spent singing. We also reverse-dialysed Area X with pharmacologic agents that act either on DA systems directly or on norepinephrine, and found that all of these agents significantly increased DA levels (3- to 10-fold) in Area X. These findings suggest that changes in extracellular DA levels can be stimulated similarly by very different social contexts (courtship and interaction with tutor), and influenced potently by dopaminergic and noradrenergic drugs. These results raise the possibility that the arousal level or attentional state of the subject (rather than singing behavior) is the common feature eliciting changes in extracellular DA concentration.
机译：越来越多的证据表明，在孤独唱歌和唱歌之间的转换中，多巴胺（DA）参与了专门唱歌的斑马雀皮层-基底神经节回路中神经活动和基因表达的改变。我们的目的是抽样调查成年和幼鸟X区域DA中胞外DA浓度的变化，以检验在两个年龄组中出现社会重要刺激时DA水平也会类似变化的假设。我们使用微渗析技术在清醒，行为成熟和成年雄性斑马雀的情况下对X区域的细胞外环境进行采样，并使用高效液相色谱结合电化学检测对透析液进行了分析。在女性向成年男性展示和家庭教师向未成年男性展示期间，X区的DA细胞外水平均显着增加。 DA水平与歌唱时间无关。我们还使用直接作用于DA系统或去甲肾上腺素的药理剂对X区进行了逆透析，发现所有这些试剂均显着提高了X区的DA水平（3至10倍）。这些发现表明，可以通过完全不同的社会环境（法院和与导师的互动）来刺激细胞外DA水平，并通过多巴胺能和去甲肾上腺素能药物来有效地影响细胞外DA水平。这些结果增加了受试者的唤醒水平或注意力状态（而不是歌唱行为）是引发细胞外DA浓度变化的共同特征的可能性。

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