• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Dynamic reorganization of neural activity in motor cortex during new sequence production
【24h】

Dynamic reorganization of neural activity in motor cortex during new sequence production

机译：新序列产生过程中运动皮层神经活动的动态重组

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although previous studies have shown that primary motor cortex (M1) neurons are modulated during the performance of a sequence of movements, it is not known how this neural activity in the M1 reorganizes during new learning of sequence-dependent motor skills. Here we trained monkeys to move to each of four spatial targets to produce multiple distinct sequences of movements in which the spatial organization of the targets determined uniquely the serial order of the movements. After the monkeys memorized the sequences, we changed one element of these over-practised sequences and the subjects were required to learn the new sequence through trial and error. When one element in an over-learned four-element sequence was changed, the sequence-specific neural activity was totally disrupted, but relatively minor changes in the direction-specific activity were observed. The data suggest that sequential motor skills are represented within M1 in the context of the complete sequential behavior rather than as a series of single consecutive movements; and sequence-specific neurons in the M1 are involved in new learning of sequence by using memorized knowledge to acquire complex motor skill efficiently.
机译：尽管以前的研究表明，运动序列执行期间会调节初级运动皮层（M1）神经元，但尚不知道在M1的这种神经活动如何在新学习依赖序列的运动技能期间会如何重组。在这里，我们训练猴子移动到四个空间目标中的每一个，以产生多个不同的运动序列，其中目标的空间组织唯一地确定了运动的序列。猴子记住了序列后，我们改变了这些过度练习的序列中的一个元素，要求受试者通过反复试验来学习新的序列。当改变一个过度学习的四元素序列中的一个元素时，该序列特异性神经活动被完全破坏，但观察到方向特异性活性相对较小的变化。数据表明，在M1中，顺序运动技能是在完整的顺序行为的背景下表示的，而不是一系列连续的单个动作。 M1中的特定序列神经元和序列特定神经元通过记忆的知识有效地掌握复杂的运动技能，从而参与了序列的新学习。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号