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首页> 外文期刊>The European Journal of Neuroscience >Topological organization of CA3-to-CA1 excitation
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Topological organization of CA3-to-CA1 excitation

机译：CA3-to-CA1激发的拓扑组织

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The CA1-projecting axons of CA3 pyramidal cells, called Schaffer collaterals, constitute one of the major information flow routes in the hippocampal formation. Recent anatomical studies have revealed the non-random structural connectivity between CA3 and CA1, but little is known regarding the functional connectivity (i.e. how CA3 network activity is functionally transmitted downstream to the CA1 network). Using functional multi-neuron calcium imaging of rat hippocampal slices, we monitored the spatiotemporal patterns of spontaneous CA3 and CA1 burst activity under pharmacological GABAergic blockade. We found that spatially clustered CA3 activity patterns were transformed into layered CA1 activity sequences. Specifically, synchronized bursts initiated from multiple hot spots in CA3 ensembles, and CA1 neurons located deeper in the pyramidal cell layer were recruited during earlier phases of the burst events. The order of these sequential activations was maintained across the bursts, but the sequence velocity varied depending on the inter-burst intervals. Thus, CA3 axons innervate CA1 neurons in a highly topographical fashion.
机译：CA3锥体细胞的CA1投射轴突，称为Schaffer侧支，构成海马结构中主要的信息流动途径之一。最近的解剖学研究已经揭示了CA3和CA1之间的非随机结构连通性，但是对于功能连通性（即CA3网络活动如何在功能上向下游传输到CA1网络）知之甚少。使用大鼠海马切片的功能性多神经元钙成像，我们在药理GABA能阻断下监测了自发CA3和CA1爆发活性的时空模式。我们发现，空间上聚集的CA3活动模式已转换为分层的CA1活动序列。具体而言，在爆发事件的早期阶段，从CA3集合体中的多个热点启动了同步爆发，并招募了位于锥体细胞层较深的CA1神经元。这些连续激活的顺序在整个突发中都保持不变，但是序列速度取决于突发间隔。因此，CA3轴突以高度拓扑的方式支配CA1神经元。

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