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首页> 外文期刊>The European Journal of Neuroscience >Regional quantification of developing human cortical shape with a three-dimensional surface-based magnetic resonance imaging analysis in utero.
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Regional quantification of developing human cortical shape with a three-dimensional surface-based magnetic resonance imaging analysis in utero.

机译：在子宫中使用基于三维表面的磁共振成像分析对人类皮质形状进行发育的区域量化。

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Although regional differences in cerebral volume have been revealed in developing human brains, little is known regarding the regionalization of cortical shape. This study documented the regional and quantitative shape difference of cortical surfaces for in utero normal fetal brains over a time period essential for the formation of primary cortical folding (22-33 weeks). Each brain surface with complete three-dimensional morphology was manually extracted from the reconstructed image, which combined surface information from three orthogonal magnetic resonance images in utero. An innovative parcellation was used to dissect the fetal brains into frontal, parietal, temporal and occipital lobes, and to avoid the determination of non-existent and immature sulci for young fetuses. Distinct cortical shapes were encoded by the shape index automatically. The results of this study show faster shape changes in the occipital lobe than in other regions. Both regional and global shape patterns show that the gyral surface smoothens, whereas the sulcal surface becomes more angular, with gestational age. In addition, the smoothing of gyri is related mainly to the changes in shape of gyral crowns. This study presents the regional differences in early gyrification from the novel aspect of shape. The results of shape pattern analysis for normal fetuses may act as a reference in assessments of prenatal brain pathology and in extensive comparisons between various life stages.
机译：尽管在人类大脑发育过程中已经揭示了大脑体积的区域差异，但对于皮质形状的区域化知之甚少。这项研究记录了子宫内正常胎儿大脑皮质表面的区域性和定量形状差异，该时间对于形成初级皮质折叠至关重要（22-33周）。从重建的图像中手动提取具有完整三维形态的每个脑表面，该图像将子宫中三个正交磁共振图像的表面信息组合在一起。一种创新的细胞分裂技术将胎儿的大脑解剖为额叶，顶叶，颞叶和枕叶，并避免了年轻胎儿的不存在和未成熟的龈沟的确定。不同的皮质形状由形状索引自动编码。这项研究的结果表明枕叶的形状变化比其他区域更快。区域形状和整体形状图案都表明，随着胎龄的增加，回旋表面变光滑，而龈沟表面则变得更加有棱角。另外，回旋的平滑化主要与回旋冠的形状变化有关。这项研究从形状的新颖方面提出了早期回旋的区域差异。正常胎儿的形状模式分析结果可作为评估产前脑病理学以及在各个生命阶段之间进行广泛比较的参考。

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