...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Induction and expression of abnormal involuntary movements is related to the duration of dopaminergic stimulation in 6-OHDA-lesioned rats.
【24h】

Induction and expression of abnormal involuntary movements is related to the duration of dopaminergic stimulation in 6-OHDA-lesioned rats.

机译：异常非自愿运动的诱导和表达与6-OHDA损伤大鼠中多巴胺能刺激的持续时间有关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dyskinesia induction in Parkinson's disease (PD) appears less marked with long-acting dopamine agonists than with short-acting L-Dopa, but the relationship to duration of drug action is unknown. It is also unclear whether the duration of drug action affects the expression of established dyskinesia. This study compared the ability of L-Dopa and four dopamine agonists of different duration of action to induce abnormal involuntary movements (AIMs) in 6-hydroxydopamine (6-OHDA)-lesioned rats, and their ability to express established AIMs following prior exposure to L-Dopa. 6-OHDA-lesioned rats were treated with saline, L-Dopa/benserazide, apomorphine, ropinirole, pramipexole or pergolide once daily for 15 days. Repeated administration of the short-acting dopamine agonists, apomorphine (duration 80 min) and ropinirole (duration 90 min) induced marked axial, limb and orolingual AIMs at peak effect. L-Dopa (duration 100 min) produced moderate AIMs at peak effect, while administration of the long-acting dopamine agonists, pramipexole (duration 150 min) and pergolide (duration 240 min) resulted in mild AIMs. In rats primed to exhibit severe AIMs following repeated L-Dopa administration, acute administration of apomorphine, ropinirole and L-Dopa induced severe AIMs. By contrast, pramipexole and pergolide evoked only mild-moderate AIMs. Again, there was a negative correlation between duration of effect and the severity of AIMs expressed. These studies show that both the induction and expression of AIMs in 6-OHDA-lesioned rats are related to the duration of action of dopaminergic drugs. These findings suggest that continuous dopaminergic stimulation could be used both to avoid dyskinesia induction and to improve motor function in late-stage PD when troublesome dyskinesia is evident.
机译：长效多巴胺激动剂对帕金森病（PD）的运动障碍诱导作用较短效L-Dopa少，但与药物作用持续时间的关系尚不清楚。还不清楚药物作用的持续时间是否影响已建立的运动障碍的表达。这项研究比较了L-多巴和四种不同作用持续时间的多巴胺激动剂在6-羟基多巴胺（6-OHDA）损伤的大鼠中诱导异常不自主运动（AIM）的能力，以及它们在事先暴露于D-后会表达既定AIM的能力。 L多巴对6-OHDA损伤的大鼠每天用盐水，L-多巴/苄丝肼，阿扑吗啡，罗匹尼罗，普拉克索或培高利特治疗15天。重复施用短效多巴胺激动剂，阿扑吗啡（持续时间80分钟）和罗匹尼罗（持续时间90分钟）会在峰值效应时引起明显的轴向，肢体和口头AIM。 L-多巴（持续时间为100分钟）在峰值效应时产生中度AIM，而长效多巴胺激动剂，普拉克索（持续时间为150分钟）和培高利特（持续时间为240分钟）的给药导致轻度AIM。在反复重复服用L-Dopa后致敏的大鼠表现出严重的AIM，阿扑吗啡，罗匹尼罗和L-Dopa的急性给药引起了严重的AIM。相比之下，普拉克索和培高利特仅引起轻度至中度的AIM。同样，作用持续时间与表达的AIM严重程度之间存在负相关。这些研究表明，6-OHDA损伤大鼠中AIM的诱导和表达均与多巴胺能药物的作用时间有关。这些发现表明，连续的多巴胺能刺激可用于避免运动障碍的诱发，并在明显的运动障碍明显时改善晚期PD的运动功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号