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首页> 外文期刊>The European Journal of Neuroscience >Dissecting mechanisms of reconsolidation: octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus.
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Dissecting mechanisms of reconsolidation: octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus.

机译：解剖再巩固的机制：章鱼胺揭示了Chasmagnathus蟹的食性和厌恶性记忆之间的差异。

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摘要

Ample evidence suggests that, when reactivated by a reminder, a consolidated memory may return to a labile state and needs to be stabilized again in order to persist, a process known as reconsolidation. In a previous study, performed in the crab Chasmagnathus, we found a dual role for the biogenic amine octopamine (OA) during memory consolidation. On the one hand, it was necessary for appetitive memory formation and, on the other, it had a deleterious effect on aversive memory consolidation. Thus, OA could be a good candidate to dissect the neurochemical mechanisms of appetitive and aversive reconsolidation. Here, we initially characterized the reconsolidation of an appetitive memory. Then, we compared appetitive reconsolidation with its aversive counterpart regarding the implication of OA in these processes, and contrasted them with previous findings obtained in the consolidation phase. Our results demonstrate that appetitive reconsolidation takes place when animals are re-exposed to the training context, as shown by the amnesic effect of cycloheximide when applied before the reminder. In addition, the no-reinforcement during the reminder is a necessary condition for appetitive reconsolidation to occur. Remarkably, appetitive reconsolidation is neither impaired by OA receptor antagonists nor facilitated by exogenous OA, whereas aversive reconsolidation can be interfered with by OA administration. Thus, our results indicate that appetitive reconsolidation does not involve OA signaling, while aversive reconsolidation is negatively modulated by OA. All in all, these results could constitute a step towards the identification of particular features of appetitive and aversive reconsolidation.
机译：大量证据表明，当通过提醒重新激活整合的内存时，它可能会返回不稳定状态，并且需要再次稳定才能持久，这一过程称为重新整合。在先前的一项研究中，我们在螃蟹Chasmagnathus中进行了研究，我们发现生物巩固胺章鱼胺（OA）在记忆巩固中起着双重作用。一方面，形成有记忆的记忆是必要的，另一方面，它对厌恶记忆的整合具有有害作用。因此，OA可能是剖析食性和厌恶性重组的神经化学机制的良好候选者。在这里，我们最初将特征性的记忆性记忆重新整合为特征。然后，我们比较了在这些过程中OA的含义，将竞争性合并与厌恶性合并进行了比较，并将它们与合并阶段获得的先前发现进行了对比。我们的结果表明，当动物再次暴露于训练环境中时，就会发生食欲强固的整合，如在提醒之前使用环己酰亚胺的记忆消除效果所示。另外，提醒期间的不强化是发生竞争性巩固的必要条件。值得注意的是，OA受体拮抗剂既不会损害食欲性的巩固，外源性OA也不会促进食性的巩固，而OA的施用会干扰厌恶性的巩固。因此，我们的结果表明，竞争性重新整合不涉及OA信号传导，而厌恶性重新整合受到OA的负面调节。总而言之，这些结果可能构成朝着确定竞争性和厌恶性合并的特定特征迈出的一步。

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