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首页> 外文期刊>The European Journal of Neuroscience >Local remapping of place cell firing in the Tolman detour task.
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Local remapping of place cell firing in the Tolman detour task.

机译：在Tolman绕行任务中对位置单元点火进行本地重映射。

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The existence of place cells, whose discharge is strongly related to a rat's location in its environment, has led to the proposal that they form part of an integrated neural system dedicated to spatial navigation. It has been suggested that this system could represent space as a cognitive map, which is flexibly used by animals to plan new shortcuts or efficient detours. To further understand the relationships between hippocampal place cell firing and cognitive maps, we examined the discharge of place cells as rats were exposed to a Tolman-type detour problem. In specific sessions, a transparent barrier was placed onto the maze so as to block the shortest central path between the two rewarded end locations of a familiar three-way maze. We found that rats rapidly and consistently chose the shortest alternative detour. Furthermore, both CA1 and CA3 place cells that had a field in the vicinity of the barrier displayed local remapping. In contrast, neither CA1 nor CA3 cells that had a field away from the barrier were affected. This finding, at odds with our previous report of altered CA3 discharge for distant fields in a shortcut task, suggests that the availability of a novel path and the blocking of a familiar path are not equivalent and could lead to different responses of the CA3 place cell population. Together, the two studies point to a specific role of CA3 in the representation of spatial connectivity and sequences.
机译：位置细胞的存在与老鼠在其周围环境中的位置密切相关，因此提出了这样的建议，即它们构成了专用于空间导航的集成神经系统的一部分。已经提出，该系统可以将空间表示为认知图，动物可以灵活地使用它来计划新的捷径或有效的弯路。为了进一步了解海马地方细胞放电与认知图之间的关系，我们检查了当大鼠暴露于Tolman型绕道问题时地方细胞的释放情况。在特定的会议中，在迷宫上放置了一个透明的屏障，以阻挡熟悉的三向迷宫的两个奖励终点位置之间的最短中央路径。我们发现大鼠迅速并始终如一地选择了最短的替代弯路。此外，CA1和CA3都将在障碍物附近具有场的单元格显示为局部重新映射。相反，场远离屏障的CA1和CA3细胞均不受影响。这一发现与我们先前关于快捷任务中远距离区域的CA3排放改变的报道不符，表明新颖路径的可用性和对熟悉路径的阻挡并不等效，并且可能导致CA3位置单元的不同响应人口。两项研究共同指出了CA3在空间连通性和序列表示中的特定作用。

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