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首页> 外文期刊>The European Journal of Neuroscience >The role of dopamine in the dorsomedial striatum in general and outcome-selective Pavlovian-instrumental transfer.
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The role of dopamine in the dorsomedial striatum in general and outcome-selective Pavlovian-instrumental transfer.

机译：多巴胺在背侧纹状体中的一般和结局选择性巴甫洛夫式器械转移中的作用。

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Pavlovian stimuli predictive of appetitive outcomes can influence the selection and initiation of instrumental behaviour. For instance, Pavlovian stimuli can act to enhance those actions with which they share an outcome, but not others with which they do not share an outcome, a phenomenon termed outcome-selective Pavlovian-instrumental transfer (PIT). Furthermore, Pavlovian stimuli can invigorate an action by inducing a general appetitive arousal that elevates instrumental responding, a phenomenon termed general PIT. The dorsomedial striatum has been implicated in outcome-selective, but not general PIT. However, the role of dopamine (DA) signals in this subregion in mediating PIT is unknown. Here we examined in rats the effects of a 6-hydroxydopamine-induced DA depletion of the anterior (aDMS) or posterior (pDMS) subregion of the dorsomedial striatum on outcome-selective and general PIT as well as on instrumental performance on a FR-5 schedule (five lever presses earned one pellet). Results demonstrate that aDMS and pDMS DA depletions compromised the rate of responding on a FR-5 schedule, suggesting that DA signals in the dorsomedial striatum are necessary to maintain high rates of instrumental responding. By contrast, aDMS and pDMS DA depletions did not affect general PIT, suggesting that DA signals in the dorsomedial striatum do not mediate general activating effects of reward-predictive stimuli to invigorate instrumental responding. Furthermore, aDMS DA depletions did not impair outcome-selective PIT, while pDMS DA depletions had no or only minor effects. Thus, DA signals in the DMS may not be involved in mediating the specific cueing effects of reward-predictive stimuli.
机译：预测结果的巴甫洛夫刺激会影响工具行为的选择和启动。例如，巴甫洛夫刺激可以增强与他们共享结果的那些行为，但不能增强与它们不共享结果的其他行为，这种现象称为结果选择性的巴甫洛夫工具转换（PIT）。此外，巴甫洛夫式刺激可以通过引起一般性食欲刺激来增强动作，从而引起工具性反应，这种现象称为一般性PIT。背侧纹状体与结果选择有关，但与一般的PIT无关。但是，该子区域中多巴胺（DA）信号在介导PIT中的作用尚不清楚。在这里，我们在大鼠中检查了6-羟基多巴胺诱导的DA耗竭对背部纹状体纹状体前部（aDMS）或后部（pDMS）区域的影响，对结果选择性和一般PIT以及FR-5的器械性能有影响日程安排（五台压力机获得一粒颗粒）。结果表明，aDMS和pDMS DA耗竭损害了FR-5计划的反应率，这表明背纹状体中的DA信号对于维持较高的仪器反应率是必要的。相比之下，aDMS和pDMS DA的耗竭并不影响一般的PIT，这表明背侧纹状体中的DA信号不会介导奖励预测性刺激的一般激活作用，以激发仪器响应。此外，aDMS DA消耗不会损害对结果有选择性的PIT，而pDMS DA消耗则没有或只有很小的影响。因此，DMS中的DA信号可能不参与介导奖励预测刺激的特定提示效果。

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