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首页> 外文期刊>The European Journal of Neuroscience >Gastrectomy alters emotional reactivity in rats: neurobiological mechanisms.
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Gastrectomy alters emotional reactivity in rats: neurobiological mechanisms.

机译：胃切除术可改变大鼠的情绪反应：神经生物学机制。

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Gastrectomy (Gsx) is associated with altered emotional function and a predisposition to depression/anxiety disorders. Here we investigated the effects of Gsx on emotional reactivity in rats and explored the underlying neurobiological mechanisms. Gsx- and sham-operated rats were exposed to behavioural tests that explore anxiety- and depression-like behaviour (open field, black and white box, elevated plus maze, social interaction, forced swim) as well as memory (object recognition). The potential neurobiological mechanisms underlying these differences were explored by measuring (i) turnover of candidate neurotransmitter systems in the nucleus accumbens, (ii) hippocampal neurogenesis by BrdU labelling or by analysis of candidate genes involved in neuronal growth and (iii) changes in mRNA expression of candidate genes in dissected hippocampal and amygdala tissue. Data from individual behavioural tests as well as from multivariate analysis revealed differing emotional reactivity between Gsx- and sham-operated rats. Gsx rats showed reduced emotional reactivity in a new environment and decreased depression-like behaviour. Accumbal serotonin and dopamine turnover were both reduced in Gsx rats. Gsx also led to a memory deficit, although hippocampal neurogenesis was unaffected. Of the many candidate genes studied by real-time RT-PCR, we highlight a Gsx-associated decrease in expression of Egr-1, a transcription factor linked to neural plasticity and cognition, in the hippocampus and amygdala. Thus, Gsx induces an alteration of emotional reactivity and a memory/cognitive deficit that is associated with reduced turnover of serotonin and dopamine in the nucleus accumbens and decreased expression of Egr-1 in the hippocampus and amygdala.
机译：胃切除术（Gsx）与情绪功能改变和抑郁/焦虑症的易感性有关。在这里，我们研究了Gsx对大鼠情绪反应的影响，并探讨了潜在的神经生物学机制。 Gsx和假手术大鼠进行行为测试，以探索焦虑和抑郁样行为（开放视野，黑白框，高架迷宫，社交互动，强迫游泳）以及记忆力（对象识别）。通过测量（i）伏隔核中候选神经递质系统的更新，（ii）通过BrdU标记进行海马神经发生或通过分析涉及神经元生长的候选基因和（iii）mRNA表达的变化，探索了潜在的神经生物学机制。海马和杏仁核组织中候选基因的表达来自个体行为测试以及多元分析的数据显示，Gsx和假手术大鼠之间的情绪反应性不同。 Gsx大鼠在新的环境下表现出降低的情绪反应，并降低了抑郁样行为。 Gsx大鼠体内的累积血清素和多巴胺代谢均降低。尽管海马神经发生不受影响，但Gsx还导致记忆力减退。在通过实时RT-PCR研究的许多候选基因中，我们强调了海马和杏仁核中与神经可塑性和认知有关的转录因子Egr-1的表达与Gsx相关的减少。因此，Gsx诱导情绪反应的改变和记忆/认知缺陷，这与伏隔核中5-羟色胺和多巴胺的更新减少以及海马和杏仁核中Egr-1的表达降低有关。

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