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首页> 外文期刊>The European Journal of Neuroscience >Medium spiny neurons of the neostriatal matrix exhibit specific, stereotyped changes in dendritic arborization during a critical developmental period in mice.
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Medium spiny neurons of the neostriatal matrix exhibit specific, stereotyped changes in dendritic arborization during a critical developmental period in mice.

机译：在小鼠的关键发育时期，新纹状体基质的中棘神经元在树突状乔化中表现出特定的，定型的变化。

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摘要

In mice, the matrix compartment of the striatum (caudate/putamen) undergoes major developmental changes during the second postnatal week, including the establishment of corticostriatal and nigrostriatal afferents, the maturation of parvalbumin-positive interneurons and the appearance of perineuronal nets. It is not known if any of these events influence the dendritic structure of medium spiny neurons, the principal output cells of the striatum. To determine whether any measurable changes in the dendrites of matrix medium spiny neurons occur during this important developmental period, we labeled individual cells at different time points flanking the second postnatal week. These cells exhibit distinct dendritic morphologies from the earliest postnatal time points examined. Furthermore, our data show that the dendritic arbors of these neurons change in length, branch points, diameter and tortuosity, regardless of morphological type. The increase in dendritic length is accompanied by a decrease in the number of branch points that occur in different, but consistent, parts of the dendritic arbor. All of these changes are most pronounced during the second postnatal week, coinciding with a number of developmental events considered important for consolidating circuitry within the striatal matrix. Our results further support the critical importance of this early postnatal period in striatal development.
机译：在小鼠中，在出生后第二周，纹状体的基质隔室（尾状/丘状）发生了重大的发育变化，包括皮质皮质和黑质纹状体的传入，小白蛋白阳性中间神经元的成熟以及神经周神经网的出现。目前尚不清楚这些事件中的任何一个是否影响中突棘神经元（纹状体的主要输出细胞）的树突结构。为了确定在这个重要的发育时期基质基质多刺神经元树突中是否发生任何可测量的变化，我们在出生后第二周的不同时间点标记了单个细胞。从最早的产后时间点来看，这些细胞显示出独特的树突形态。此外，我们的数据显示，这些神经元的树突状树突在长度，分支点，直径和曲折度上均发生变化，而与形态类型无关。树突长度的增加伴随着在不同但一致的部分树突乔木中出现的分支点数量的减少。所有这些变化在产后第二周最为明显，这与许多对巩固纹状体基质内的回路很重要的发育事件相吻合。我们的结果进一步支持了出生后早期在纹状体发育中的至关重要性。

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