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首页> 外文期刊>The European Journal of Neuroscience >Phantom digit somatotopy: A functional magnetic resonance imaging study in forearm amputees
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Phantom digit somatotopy: A functional magnetic resonance imaging study in forearm amputees

机译：幻影躯体解剖学：前臂截肢者的功能磁共振成像研究

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摘要

Forearm amputees often experience non-painful sensations in their phantom when the amputation stump is touched. Cutaneous stimulation of specific stump areas may be perceived as stimulation of specific phantom fingers (stump hand map). The neuronal basis of referred phantom limb sensations is unknown. We used functional magnetic resonance imaging to demonstrate a somatotopic map of the phantom fingers in the hand region of the primary somatosensory cortex after tactile stump stimulation. The location and extent of phantom finger activation in the primary somatosensory cortex corresponded well to the location of normal fingers in a reference population. Stimulation of the stump hand map resulted in an increased bilateral activation of the primary somatosensory cortex compared with stimulation of forearm regions outside the stump hand map. Increased activation was also seen in contralateral posterior parietal cortex and premotor cortex. Ipsilateral primary somatosensory cortex activation might represent a compensatory mechanism and activation of the non-primary fronto-parietal areas might correspond to awareness of the phantom limb, which is enhanced when experiencing the referred sensations. It is concluded that phantom sensation elicited by stimulation of stump hand map areas is associated with activation of finger-specific somatotopical representations in the primary somatosensory cortex. This suggests that the primary somatosensory cortex could be a neural substrate of non-painful phantom sensations. The stump hand map phenomenon might be useful in the development of prosthetic hand devices.
机译：触碰截肢残肢时，前臂截肢者通常会在幻影中产生非痛感。特定树桩区域的皮肤刺激可被视为对特定幻影手指的刺激（树桩手图）。提到的幻肢感觉的神经元基础是未知的。我们使用功能磁共振成像来证明触觉树桩刺激后，在主要体感皮层的手部区域中的幻影手指的体位图。体感皮层中幻影手指激活的位置和程度与参考人群中正常手指的位置非常吻合。与刺激树桩手图外的前臂区域相比，树桩手图的刺激导致初级体感皮层的双边激活增加。在对侧后顶叶皮层和运动前皮层中也发现激活增加。同侧的主要体感皮层激活可能代表一种补偿机制，非主要的额顶区域的激活可能对应于幻肢的意识，当体验到所提及的感觉时，这种感觉会增强。结论是，通过刺激残端手部图区域引起的幻觉与在主要体感皮层中手指特异性体位表征的激活有关。这表明主要的体感皮层可能是非疼痛幻影感觉的神经基质。残端手部地图现象可能在假肢手部设备的开发中很有用。

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