Neonatal seizures: Controversies and challenges in translating new therapies from the lab to the isolette

ChapmanK.E.; RaolY.H.; Brooks-KayalA.

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Neonatal seizures: Controversies and challenges in translating new therapies from the lab to the isolette

机译：新生儿癫痫发作：将新疗法从实验室转化为isolette的争议和挑战

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Neonatal seizures have unique properties that have proved challenging for both clinicians and basic science researchers. Clinical therapies aimed at neonatal seizures have proven only partially effective and new therapies are slow to develop. This article will discuss neonatal seizures within the framework of the barriers that exist to the development of new therapies, and the challenges inherent in bringing new therapies from the bench to the bedside. With the European Union and USA creating national collaborative project infrastructure, improved collaborative resources should advance clinical research on urgently needed new therapies for this disorder.

机译：新生儿癫痫发作具有独特的性质，已证明对临床医生和基础科学研究人员都具有挑战性。事实证明，针对新生儿癫痫发作的临床疗法仅部分有效，并且新疗法的开发缓慢。本文将在新疗法开发存在的障碍的框架内讨论新生儿癫痫发作，以及将新疗法从实验台带到床边的固有挑战。随着欧洲联盟和美国创建国家合作项目基础设施，改进的合作资源将推动针对该疾病迫切需要的新疗法的临床研究。

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《The European Journal of Neuroscience》 |2012年第12期|共9页
作者
ChapmanK.E.; RaolY.H.; Brooks-KayalA.;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Epilepsy; Rodent models; Translational research; Treatment;

机译：癫痫;啮齿动物模型;转化研究;治疗;

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1. Neonatal seizures: Controversies and challenges in translating new therapies from the lab to the isolette [J] . ChapmanK.E., RaolY.H., Brooks-KayalA. The European Journal of Neuroscience . 2012,第11a12期

机译：新生儿癫痫发作：将新疗法从实验室转化为isolette的争议和挑战
2. Extracellular Vesicles as a Potential Therapy for Neonatal Conditions: State of the Art and Challenges in Clinical Translation [J] . Andreea C. Matei, Lina Antounians, Augusto Zani Pharmaceutics . 2019,第8期

机译：细胞外囊泡作为新生儿疾病的潜在疗法：技术现状和临床翻译中的挑战
3. Extracellular Vesicles as a Potential Therapy for Neonatal Conditions: State of the Art and Challenges in Clinical Translation [J] . Andreea C. Matei, Lina Antounians, Augusto Zani Pharmaceutics . 2019,第8期

机译：细胞外囊泡作为新生儿疾病的潜在疗法：技术现状和临床翻译中的挑战
4. Extraction of temporal motor activity signals from video recordings of neonatal seizures by improved feature tracking methods based on translation motion models [C] . Karayiannis, N.B., Yaohua Xiong Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE . 2003

机译：通过基于平移运动模型的改进特征跟踪方法从新生儿癫痫发作的录像中提取颞运动活动信号
5. Design of a simulator for neonatal multichannel EEG: Application to time-frequency approaches for automatic artifact removal and seizure detection. [D] . Al-Sa'd, Mohamed Fathi. 2016

机译：新生儿多通道脑电图模拟器的设计：应用于时频方法以自动去除伪影和癫痫发作。
6. Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette [O] . Kevin E. Chapman, Yogendra H. Raol, Amy Brooks-Kayal -1

机译：新生儿癫痫发作：将新疗法从实验室转化为隔离物的争论和挑战
7. Translations, Betrayals and Controversies in the Articulation of The Uncertainty Principle: Potentialities and Challenges of a Symmetrical History of Physics [O] . Nathan Willig Lima, Gabriela Gomes Rosa, Miguel Rocha Bento 2020

机译：翻译，背叛和争论在不确定原则的阐述中：物理学对称史的潜力和挑战

Neonatal seizures: Controversies and challenges in translating new therapies from the lab to the isolette

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