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首页> 外文期刊>The European Journal of Neuroscience >Spatial localization and projection densities of brainstem mossy fibre afferents to the forelimb C1 zone of the rat cerebellum.
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Spatial localization and projection densities of brainstem mossy fibre afferents to the forelimb C1 zone of the rat cerebellum.

机译：大鼠小脑前肢C1区传入的脑干苔藓纤维的空间定位和投射密度。

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摘要

The present study uses a double retrograde tracer technique in rats to examine the spatial localization and pattern of axonal branching in mossy fibres arising from three major sources in the medulla-the external cuneate nucleus, the sensory trigeminal nucleus and the reticular formation, to two electrophysiologically-identified parts of the cerebellar cortex that are linked by common climbing fibre input - the forelimb-receiving parts of the C1 zone in lobulus simplex and the paramedian lobule. In each experiment a small injection of rhodamine-tagged beads was injected into one cortical region and an injection of fluorescein-tagged beads was injected into the other region. The main findings were: (i) the proportion of double-labelled cells in each of the three precerebeller sources of mossy fibres was positively correlated with those in the inferior olive; and (ii) the C1 zone in lobulus simplex was found to receive a greater density of projections from all three sources of mossy fibres than the C1 zone in the paramedian lobule. These data suggest that two rostrocaudally separated but somatotopically corresponding parts of the C1 zone receive common mossy fibre and climbing fibre inputs. However, the differences in projection densities also suggest that the two parts of the zone differ in the extent to which they receive mossy fibre signals arising from the same precerebellar nuclei. This implies differences in function between somatotopically corresponding parts of the same cortical zone, and could enable a higher degree of parallel processing and integration of information within them.
机译：本研究在大鼠中使用双重逆行示踪技术，检查了由延髓中的三个主要来源（楔形外核，感觉三叉神经核和网状结构）的三个主要来源产生的苔藓纤维中的轴突分支的空间定位和模式。常见的攀爬纤维输入将小脑皮层的识别部分连接在一起-单纯小叶和旁中叶小叶C1区的前肢接收部分。在每个实验中，将少量注射若丹明标签的珠子注射到一个皮质区域，并注射荧光素标签的珠子注射到另一皮质区域。主要发现是：（i）三种前脑长满苔藓纤维的来源中，双标记细胞的比例与下橄榄中的细胞呈正相关; （ii）发现在三个部位的苔藓纤维中，单纯小叶的C1区比旁中叶的C1区具有更高的投影密度。这些数据表明，C1区域的两个在尾鳍上分开但在体位上相对应的部分接收到普通的苔藓纤维和攀爬纤维输入。但是，投射密度的差​​异还表明，该区域的两个部分在接收由相同小脑前核产生的苔藓纤维信号的程度上也有所不同。这意味着同一皮质区的体位对应部分之间的功能差异，并且可以在其中进行更高程度的并行处理和信息整合。

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