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首页> 外文期刊>The European Journal of Neuroscience >γ-Aminobutyric acid receptor A-mediated inhibition in the honeybee's antennal lobe is necessary for the formation of configural olfactory percepts
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γ-Aminobutyric acid receptor A-mediated inhibition in the honeybee's antennal lobe is necessary for the formation of configural olfactory percepts

机译：γ-氨基丁酸受体A介导的蜜蜂触角叶抑制是形成构型嗅觉的必要条件

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摘要

Complex odours often possess perceptual qualities that are distinct from their components. Previous studies in humans, rodents, and insects indicate that the perception of complex odour blends depends on the concentration of the components and the mixture's complexity. However, we know relatively little about the way that an odour mixture 'gestalt' is produced by the olfactory system. Here, using an assay for olfactory conditioning in the honeybee (Apis mellifera), we examine the role of γ-aminobutyric acid receptor A (GABA A)-ergic inhibition within the olfactory primary relay, the antennal lobe, in the formation of a unique odour percept for complex odours. We found that honeybees perceive odour mixtures as configural stimuli when the mixtures were of low concentration and when they were composed of more than two odorants. When GABA A receptors were disrupted using the antagonist, picrotoxin, injected directly into the antennal lobe, we observed that bees no longer perceived the mixture as a configural stimulus. Our results imply that synchronization of antennal lobe projection neurons mediated by GABA A receptors is the mechanism responsible for the formation of unique olfactory percepts for complex odours.
机译：复杂的气味通常具有与其成分不同的感知特性。先前对人类，啮齿动物和昆虫的研究表明，对复杂气味混合物的感知取决于组分的浓度和混合物的复杂性。但是，我们对嗅觉系统产生气味混合物“格式塔”的方式知之甚少。在这里，我们使用一种用于蜜蜂（Apis mellifera）中的嗅觉调节的测定方法，研究了嗅觉初级继电器（触角叶）内γ-氨基丁酸受体A（GABA A）的能量抑制作用在独特的形成中的作用。闻到复杂气味的气味。我们发现，当蜜蜂的气味混合物浓度低且由两种以上的气味物质组成时，它们会将气味混合物视为构象刺激。当使用直接注入触角叶的拮抗剂微毒素破坏GABA A受体时，我们观察到蜜蜂不再将混合物视为结构性刺激。我们的结果表明，由GABA A受体介导的触角投射神经元的同步化是负责形成复杂气味的独特嗅觉的机制。

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