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首页> 外文期刊>The European Journal of Neuroscience >Normal aging modulates prefrontoparietal networks underlying multiple memory processes
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Normal aging modulates prefrontoparietal networks underlying multiple memory processes

机译：正常老化可调节多个存储过程基础的额前绝经网络

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A functional decline of brain regions underlying memory processing represents a hallmark of cognitive aging. Although a rich literature documents age-related differences in several memory domains, the effect of aging on networks that underlie multiple memory processes has been relatively unexplored. Here we used functional magnetic resonance imaging during working memory and incidental episodic encoding memory to investigate patterns of age-related differences in activity and functional covariance patterns common across multiple memory domains. Relative to younger subjects, older subjects showed increased activation in left dorso-lateral prefrontal cortex along with decreased deactivation in the posterior cingulate. Older subjects showed greater functional covariance during both memory tasks in a set of regions that included a positive prefronto-parietal-occipital network as well as a negative network that spanned the default mode regions. These findings suggest that the memory process-invariant recruitment of brain regions within prefronto-parietal-occipital network increases with aging. Our results are in line with the dedifferentiation hypothesis of neurocognitive aging, thereby suggesting a decreased specialization of the brain networks supporting different memory networks. Aging is associated with memory decline. Here we investigated age-related changes in brain responses across multiple memory domains. Older subjects had a greater engagement of a prefronto-parietal-occipital network relative to younger subjects during working memory (A, B) and the encoding phase of episodic memory (C). Our findings lend support to the dedifferentiation hypothesis of cognitive aging.
机译：记忆处理基础的大脑区域功能下降代表认知老化的标志。尽管丰富的文献记载了在几个内存域中与年龄相关的差异，但是相对而言，老化对作为多个内存进程基础的网络的影响尚未得到充分研究。在这里，我们在工作记忆和偶发事件编码记忆期间使用了功能磁共振成像，以研究与年龄相关的活动差异模式和跨多个记忆域常见的功能协方差模式。相对于年轻的受试者，年龄较大的受试者显示左背外侧前额叶皮层的激活增加，而后扣带回的减少。年龄较大的受试者在两个记忆任务期间在一组区域中表现出更大的功能协方差，这些区域包括正的额前顶叶枕网络和负的网络，这些网络跨越默认模式区域。这些发现表明，随着年龄的增长，前额顶叶枕网络内大脑区域的记忆过程不变募集。我们的结果与神经认知衰老的去分化假说相符，从而表明支持不同记忆网络的脑网络的专业化程度下降。老化与内存减少有关。在这里，我们研究了跨多个记忆域的大脑反应中与年龄相关的变化。在工作记忆（A，B）和情景记忆的编码阶段（C），年龄较大的受试者相对于年龄较小的受试者具有更大的前额叶顶枕网络接合。我们的发现为认知衰老的去分化假说提供了支持。

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