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首页> 外文期刊>The European Journal of Neuroscience >Engrailed signaling in axon guidance and neuron survival
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Engrailed signaling in axon guidance and neuron survival

机译：轴突引导和神经元存活过程中的信号转导。

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Several homeoproteins can function in a direct cell non-autonomous fashion to control various biological processes. In the developing nervous system, this mode of signaling has been well documented for Engrailed in the guidance of retinal ganglion cell axons and retino-tectal patterning. Engrailed is also a key factor for mesencephalic dopaminergic (mDA) neurons, not only during development but also in the adult. Haplodeficiency for Engrailed1 leads to progressive adult-onset loss of mDA neurons and several phenotypic alterations reminiscent of Parkinson's disease (PD). Thanks to its transduction properties, Engrailed has been shown to confer neuroprotection in several experimental models of PD. Study of the mechanisms underlying these two Engrailed-mediated effects has revealed a key role of the translation regulation by Engrailed and uncovered an unsuspected link between a homeoprotein and mitochondrial activity. These studies highlight the crucial role of cellular energetic metabolism in neuron development, survival and neurodegeneration, and may help to identify novel therapeutic targets.
机译：几种同源蛋白可以直接细胞非自主方式起作用，以控制各种生物学过程。在发育中的神经系统中，这种信号传导模式已被Engrailed广泛应用于视网膜神经节细胞轴突和视网膜-台架模式的指导中。陷入困境也是中脑多巴胺能神经元（mDA）的关键因素，不仅在发育过程中而且在成年人中也是如此。 Engrailed1的单倍型缺乏会导致成年发作的mDA神经元逐渐丧失，以及一些表型改变，使人想起帕金森氏病（PD）。由于其转导特性，Engrailed已在多种PD实验模型中显示出赋予神经保护的作用。对这两种Engrailed介导的作用机理的研究揭示了Engrailed调控翻译的关键作用，并揭示了同源蛋白与线粒体活性之间不可思议的联系。这些研究突出了细胞能量代谢在神经元发育，存活和神经变性中的关键作用，并可能有助于确定新的治疗靶标。

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