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首页> 外文期刊>The European Journal of Neuroscience >Different TRPV1 -mediated brain responses to intragastric infusion of capsaicin and capsiate
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Different TRPV1 -mediated brain responses to intragastric infusion of capsaicin and capsiate

机译：不同TRPV1介导的对辣椒素和辣椒素胃内灌注的大脑反应

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摘要

Capsaicin and capsiate, which is an analogue of capsaicin, are agonists of capsaicin-binding transient potential vanilloid 1 (TRPV1) receptors. However, their physiological effects are different. Capsaicin induces thermogenesis and nociception, while the different kinetics of capsiate result in thermogenesis without nociception in the oral cavity. In the present study, using functional magnetic resonance imaging, we compared the brain activation after intragastric infusion of non-nociceptive levels of capsaicin and capsiate in wild-type and TRPV1-knockout (КО) mice. Capsaicin activated several brain regions, such as the periaqueductal grey (PAG), thalamic nuclei and hypothalamus, including the medial preoptic area (mPOA) and ventromedial hypothalamus (VMH). Most of these areas were not activated in TRPV1-KO mice. Capsiate activated several regions, including the thalamic nuclei, mPOA and VMH but not PAG in wild-type mice. Most of the activated areas were not activated by intragastric capsiate infusion in TRPV1-KO mice. These results demonstrate that TRPV1 is critical for the induction of activation in the hypothalamus by capsaicin and capsiate, and these distinct brain activations could help to explain the individual physiological reactions of capsaicin and capsiate.
机译：辣椒素和辣椒素是辣椒素的类似物，是辣椒素结合瞬时电位香草酸1（TRPV1）受体的激动剂。但是，它们的生理作用是不同的。辣椒素诱导生热和伤害感受，而辣椒素的不同动力学导致生热，而口腔中没有伤害感受。在本研究中，我们使用功能性磁共振成像，比较了野生型和TRPV1基因敲除（КО）小鼠胃内输注辣椒碱和辣椒碱的非伤害性水平后的大脑激活情况。辣椒素激活了几个大脑区域，例如导水管周围的灰色（PAG），丘脑核和下丘脑，包括视前内侧区域（mPOA）和腹膜下丘脑（VMH）。这些区域大多数在TRPV1-KO小鼠中未激活。衣壳激活了几个区域，包括丘脑核，mPOA和VMH，但没有激活PAG。在TRPV1-KO小鼠中，大多数激活区域未通过胃内衣壳内灌注激活。这些结果表明，TRPV1对于辣椒素和辣椒素诱导下丘脑的激活至关重要，而这些独特的脑部激活可以帮助解释辣椒素和辣椒素的个别生理反应。

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