Dual effects of NMDA receptor activation on polysialylated neural cell adhesion molecule expression during brainstem postnatal development.

Bouzioukh F; Tell F; Rougon G; Jean A

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Dual effects of NMDA receptor activation on polysialylated neural cell adhesion molecule expression during brainstem postnatal development.

机译：NMDA受体激活对脑干出生后发育过程中多唾液酸化神经细胞粘附分子表达的双重影响。

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Here we show a dual role of N-methyl-d-aspartate receptor (NMDAR) activation in controlling polysialylated neural cell adhesion molecule (PSA-NCAM) dynamic expression in the dorsal vagal complex (DVC), a gateway for many primary afferent fibres. In this structure the overall expression of PSA-NCAM decreases during the first 2 weeks after birth to persist only at synapses in the adult. Electrical stimulation of the vagal afferents causes a rapid increase of PSA-NCAM expression both in vivo and in acute slices before postnatal day (P) 14 whereas a similar stimulation induces a decrease after P15. Inhibition of NMDAR activity in vitro completely prevented these changes. These regulations depend on calmodulin activation and cGMP production at all stages. By contrast, blockade of neuronal nitric oxide synthase (nNOS) prevented these changes only after P10 in agreement with its late expression in the DVC. The pivotal role of NMDAR is also supported by the observation that chronic blockade induces a dramatic decrease in PSA-NCAM expression.

机译：在这里，我们显示了N-甲基-d-天冬氨酸受体（NMDAR）激活在控制背迷走神经复合体（DVC）（许多初级传入纤维的通道）中的多唾液酸化神经细胞粘附分子（PSA-NCAM）动态表达中的双重作用。在这种结构中，PSA-NCAM的总体表达在出生后的前两周下降，仅在成年人的突触中持续存在。迷走神经传入的电刺激会导致出生后一天（P）14之前的体内和急性切片中PSA-NCAM表达迅速增加，而类似的刺激会导致P15之后的PSA-NCAM表达降低。体外抑制NMDAR活性完全阻止了这些变化。这些法规取决于钙调蛋白激活和cGMP在所有阶段的生产。相比之下，对神经元一氧化氮合酶（nNOS）的阻止只能在P10后与其在DVC中的晚期表达相一致才能阻止这些变化。慢性阻塞引起PSA-NCAM表达急剧下降的观察也支持了NMDAR的关键作用。

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来源
《The European Journal of Neuroscience》 |2001年第8期|共9页
作者
Bouzioukh F; Tell F; Rougon G; Jean A;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Aging; Neural Cell Adhesion Molecules; Receptors; N-Methyl-D-Aspartate; Sialic Acids; 衰老; 受体; N-甲基-D-天冬氨酸; 唾液酸类; 孤束核; 迷走神经; 内脏传入神经;

机译：Aging;Neural Cell Adhesion Molecules;Receptors;N-Methyl-D-Aspartate;Sialic Acids;衰老;受体;N-甲基-D-天冬氨酸;唾液酸类;孤束核;迷走神经;内脏传入神经;

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1. Dual effects of NMDA receptor activation on polysialylated neural cell adhesion molecule expression during brainstem postnatal development. [J] . Bouzioukh F, Tell F, Rougon G, The European Journal of Neuroscience . 2001,第8期

机译：NMDA受体激活对脑干出生后发育过程中多唾液酸化神经细胞粘附分子表达的双重影响。
2. Transcriptional regulation of polysialylated neural cell adhesion molecule expression by NMDA receptor activation in retinoic acid-differentiated SH-SY5Y neuroblastoma cultures. [J] . Singh J, Kaur G Brain research . 2007,第0期

机译：视黄酸分化的SH-SY5Y神经母细胞瘤培养物中NMDA受体激活对多唾液酸化神经细胞粘附分子表达的转录调控。
3. Autocrine/paracrine activation of the GABA(A) receptor inhibits the proliferation of neurogenic polysialylated neural cell adhesion molecule-positive (PSA-NCAM+) precursor cells from postnatal striatum. [J] . Nguyen L, Malgrange B, Breuskin I, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2003,第8期

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4. Highly polysialylated neural cell adhesion molecule positive cells increased and changed localization in rat hippocampus with exposure to repeated kindled seizures [C] . K. Sato, M. Iwai, W.R. Zhang, International Symposium on Molecular Mechanism and Epochal Therapeutics for Ischemic Stroke and Dementia . 2003

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5. T cell development and gamma/delta T cell antigen receptor: I. Structure and rearrangement of murine T cell antigen receptor delta chain gene. II. Expression of fetal type gamma/delta T cell receptor in adult transgenic mice and its effects on T cell development. [D] . Iwashima, Makio. 1990

机译：T细胞发育和γ/δT细胞抗原受体：I.鼠T细胞抗原受体δ链基因的结构和重排。二。胎儿型γ/δT细胞受体在成年转基因小鼠中的表达及其对T细胞发育的影响。
6. NMDA Receptor and Nitric Oxide Synthase Activation Regulate Polysialylated Neural Cell Adhesion Molecule Expression in Adult Brainstem Synapses [O] . Farima Bouzioukh, Fabien Tell, André Jean, 2001

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7. Autocrine/paracrine activation of the GABA(A) receptor inhibits the proliferation of neurogenic polysialylated neural cell adhesion molecule-positive (PSA-NCAM+) precursor cells from postnatal striatum. [O] . Nguyen, Laurent, Malgrange, Brigitte, Breuskin, Ingrid, 2003

机译：GABA（A）受体的自分泌/旁分泌激活抑制了产后纹状体的神经源性多唾液酸化神经细胞粘附分子阳性（PSA-NCAM +）前体细胞的增殖。
8. Costimulation of T Cell Receptor/CD3-Mediated Activation of Resting Human CD4+ TCells by Leukocyte Function-Associated Antigen-1 Ligand Intercellular Cell Adhesion Molecule-1 Involves Prolonged Inositol Phospholipid Hydrolysis and Sustained Increase of In [R] . Van Seventer, G. A., Bonvini, E., Yamada, H., 1992

机译：白细胞功能相关抗原-1配体细胞间粘附分子-1的T细胞受体/ CD3介导的静息人CD4 + TCell活化共刺激涉及延长的肌醇磷脂水解和持续增加的In

Dual effects of NMDA receptor activation on polysialylated neural cell adhesion molecule expression during brainstem postnatal development.

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