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首页> 外文期刊>The European Journal of Neuroscience >Cholinergic optimization of cue-evoked parietal activity during challenged attentional performance.
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Cholinergic optimization of cue-evoked parietal activity during challenged attentional performance.

机译：挑战注意力表现期间提示诱发的顶叶活动的胆碱能优化。

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摘要

The detection of salient or instrumental stimuli and the selection of cue-evoked responses are mediated by a fronto-parietal network that is modulated by cholinergic inputs originating from the basal forebrain. Visual cues that guide behavior are more strongly represented in the posterior parietal cortex (PPC) than are similar cues that are missed or task-irrelevant. Although the crucial role of cholinergic inputs in cue detection has been demonstrated by lesion studies, the role of PPC neurons in the cholinergic modulation of cue detection is unclear. We recorded extracellular spikes from PPC neurons of rats performing a sustained attention task, before and after selective removal of cholinergic inputs to the recording site. Visual cues that were subsequently detected evoked significant increases in the PPC firing rate. In the absence of cholinergic input, the activation of PPC neurons by detected cues was greatly diminished. When a visual distractor was introduced during task performance, a population of PPC neurons selectively responded to the distractor. As a result of cholinergic deafferentation, distractor-related neuronal activity was enhanced, and the detection-related activity was further suppressed. Thus, in deafferented subjects, the distractor lowered the signal-to-noise ratio of cue-evoked responses. This impairment in cue-evoked neuronal activity may have mediated the increased response latencies observed for detected cues in the presence of the distractor. Additional experiments demonstrated that the effects of cholinergic deafferentation were not confounded by extended practice or electrode depth. Collectively, these findings indicate that cholinergic inputs to PPC neurons amplify cue detection, and may also act to suppress irrelevant distractors.
机译：显着或工具性刺激的检测以及提示诱发反应的选择是由额顶网络介导的，该额顶网络由源自基底前脑的胆碱能输入调节。引导行为的视觉提示在顶叶后皮质（PPC）中的表现要强于缺少或与任务无关的类似提示。尽管病灶研究已证明胆碱能输入在提示检测中的关键作用，但尚不清楚PPC神经元在提示检测的胆碱能调节中的作用。我们在选择性去除胆碱能输入到记录位点之前和之后，记录了执行持续注意任务的大鼠PPC神经元的细胞外尖峰。随后发现的视觉提示引起了PPC触发率的显着提高。在没有胆碱能输入的情况下，通过检测到的提示对PPC神经元的激活大大减少了。在任务执行过程中引入视觉干扰器时，一群PPC神经元会选择性地对干扰器作出反应。由于胆碱能脱除咖啡因，增强了与牵张相关的神经元活性，并进一步抑制了与检测相关的活性。因此，在情绪低落的受试者中，干扰物降低了提示诱发反应的信噪比。提示诱发的神经元活动的这种损害可能已经介导了在存在干扰物的情况下对于检测到的提示观察到的响应潜伏期增加。额外的实验表明，胆碱能脱除咖啡因的影响不会因长期练习或电极深度而混淆。总而言之，这些发现表明，PPC神经元的胆碱能输入会放大提示检测，并且可能还起到抑制无关紧要的作用。

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