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首页> 外文期刊>The European Journal of Neuroscience >A direct main olfactory bulb projection to the 'vomeronasal' amygdala in female mice selectively responds to volatile pheromones from males.
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A direct main olfactory bulb projection to the 'vomeronasal' amygdala in female mice selectively responds to volatile pheromones from males.

机译：在雌性小鼠中，直接嗅嗅球直接投射到“犁鼻”杏仁核上对雄性的挥发性信息素有选择性反应。

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The main olfactory system, like the accessory olfactory system, responds to pheromones involved in social communication. Whereas pheromones detected by the accessory system are transmitted to the hypothalamus via the medial ('vomeronasal') amygdala, the pathway by which pheromones are detected and transmitted by the main system is not well understood. We examined in female mice whether a direct projection from mitral/tufted (M/T) cells in the main olfactory bulb (MOB) to the medial amygdala exists, and whether medial amygdala-projecting M/T cells are activated by volatile urinary odors from conspecifics or a predator (cat). Simultaneous anterograde tracing using Phaseolus vulgaris leucoagglutinin and Fluoro-Ruby placed in the MOB and accessory olfactory bulb (AOB), respectively, revealed that axons of MOB M/T cells projected to superficial laminae of layer Ia in anterior and posterodorsal subdivisions of the medial amygdala, whereas projection neurons from the AOB sent axons to non-overlapping, deeper layer Ia laminae of the same subdivisions. Placement of the retrograde tracer cholera toxin B into the medial amygdala labeled M/T cells that were concentrated in the ventral MOB. Urinary volatiles from male mice, but not from female conspecifics or cat, induced Fos in medial amygdala-projecting MOB M/T cells of female subjects, suggesting that information about male odors is transmitted directly from the MOB to the 'vomeronasal' amygdala. The presence of a direct MOB-to-medial amygdala pathway in mice and other mammals could enable volatile, opposite-sex pheromones to gain privileged access to diencephalic structures that control mate recognition and reproduction.
机译：像辅助嗅觉系统一样，主要嗅觉系统对参与社交沟通的信息素作出反应。辅助系统检测到的信息素是通过内侧（“犁鼻”）杏仁核传递到下丘脑的，而主系统检测和传递信息素的途径尚不清楚。我们在雌性小鼠中检查了是否存在从主要嗅球（MOB）中的二尖瓣/簇状（M / T）细胞向杏仁核内侧的直接投射，以及是否向内侧杏仁核投射的M / T细胞被来自以下部位的挥发性尿味激活了物种或捕食者（猫）。使用分别放置在MOB和副嗅球（AOB）中的菜豆白菜凝集素和Fluoro-Ruby进行同时顺行示踪，发现MOB M / T细胞的轴突投射到内侧杏仁核前部和后背区的Ia层浅层。 ，而来自AOB的投射神经元则将轴突发送到相同细分的非重叠，较深的Ia层。将逆行示踪剂霍乱毒素B放入内侧杏仁核标记的M / T细胞中，该M / T细胞集中在腹侧MOB中。雄性小鼠的尿挥发物，而不是雌性同种异体或猫的尿挥发物，在雌性受试者的杏仁体内侧投射MOB M / T细胞中诱导了Fos，这表明有关男性气味的信息直接从MOB传递至“犁鼻”杏仁核。小鼠和其他哺乳动物中存在直接的MOB到中间杏仁核通路，这可以使挥发性，异性性信息素获得对控制伴侣识别和繁殖的双脑结构的特权访问。

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