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首页> 外文期刊>The European Journal of Neuroscience >Effects of stimulation of the centromedian nucleus of the thalamus on the activity of striatal cells in awake rhesus monkeys.
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Effects of stimulation of the centromedian nucleus of the thalamus on the activity of striatal cells in awake rhesus monkeys.

机译：刺激丘脑的着丝粒中心核对清醒猕猴纹状体细胞活性的影响。

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Although the existence of a massive projection from the caudal intralaminar nuclei of the thalamus [i.e. the centromedian (CM) and parafascicular nuclei] to the striatum is well documented, the effects of CM activation upon striatal cells remain poorly understood. Therefore, we studied the effects of electrical stimulation of CM on the electrophysiological activity of striatal neurons, and on striatal levels of gamma-aminobutyric acid (GABA) and acetylcholine in rhesus monkeys. Striatal cells did not respond to single-pulse stimulation (bipolar biphasic stimulation, 175-500 muA), but the large majority of recorded neurons responded to burst stimulation (100 Hz, 1 s, 150-175 muA) of CM, often with a delay of tens of milliseconds. Striatal phasically active neurons, which likely correspond to projection neurons, responded mainly with increases in firing (13/28 cells), while tonically active neurons (likely cholinergic interneurons) often showed combinations of increases and decreases in firing (24/46 cells). In microdialysis studies, CM stimulation led to a reduction of striatal acetylcholine levels. This effect was prevented by addition of the GABA-A receptor antagonist gabazine to the microdialysis fluid. We conclude that CM stimulation frequently results in striatal response patterns with excitatory and inhibitory components. Under the conditions chosen here, the specific patterns of striatal responses to CM stimulation are likely the result of striatal processing of thalamic inputs. Through these indirect effects, local CM stimulation may engage large portions of the striatum. These effects may be relevant in the interpretation of the therapeutic effects of CM stimulation for the treatment of neurological disorders.
机译：虽然从丘脑的尾椎板层内核存在大量的投射物[即着丝粒（CM）和纹状体旁核]已有大量文献记载，但对CM激活对纹状体细胞的影响知之甚少。因此，我们研究了电刺激CM对恒河猴中纹状体神经元的电生理活动以及γ-氨基丁酸（GABA）和乙酰胆碱的纹状体水平的影响。纹状体细胞对单脉冲刺激（双极双相刺激，175-500μA）无反应，但记录的大多数神经元对CM的突发刺激（100 Hz，1 s，150-175μA）有反应，通常伴有延迟数十毫秒。可能与投射神经元相对应的纹状体有相位活跃神经元，主要以放电增加（13/28个细胞）为响应，而有声活跃神经元（可能是胆碱能中间神经元）通常表现为发射增加和减少的组合（24/46个细胞）。在微透析研究中，CM刺激导致纹状体乙酰胆碱水平降低。通过向微透析液中添加GABA-A受体拮抗剂gabazine来防止此效果。我们得出的结论是，CM刺激经常导致具有兴奋和抑制成分的纹状体反应模式。在此处选择的条件下，对CM刺激的纹状体反应的特定模式可能是丘脑输入的纹状体处理的结果。通过这些间接影响，局部CM刺激可能会刺激纹状体的大部分。这些作用可能与解释CM刺激治疗神经系统疾病的治疗作用有关。

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