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首页> 外文期刊>The European Journal of Neuroscience >Dorsal hippocampal regulation of memory reconsolidation processes that facilitate drug context-induced cocaine-seeking behavior in rats.
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Dorsal hippocampal regulation of memory reconsolidation processes that facilitate drug context-induced cocaine-seeking behavior in rats.

机译：记忆重建过程的背侧海马调控，促进药物环境诱导的大鼠可卡因寻找行为。

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Exposure to a cocaine-paired context increases the propensity for relapse in cocaine users and prompts cocaine-seeking behavior in rats. According to the reconsolidation hypothesis, upon context re-exposure, established cocaine-related associations are retrieved and can become labile. These associations must undergo reconsolidation into long-term memory to effect enduring stimulus control. The dorsal hippocampus (DH), dorsolateral caudate-putamen and dorsomedial prefrontal cortex are critical for the expression of context-induced cocaine seeking, and these brain regions may also play a role in the reconsolidation of cocaine-related memories that promote this behavior. To test this hypothesis, rats were trained to press a lever for unsignaled cocaine infusions (0.2 mg/infusion, i.v.) in a distinct environmental context (cocaine-paired context), followed by extinction training in a different context (extinction context). Rats were then re-exposed to the cocaine-paired context for 15 min in order to reactivate cocaine-related memories or received comparable exposure to a novel unpaired context. Immediately thereafter, rats received bilateral microinfusions of the protein synthesis inhibitor anisomycin, the sodium channel blocker tetrodotoxin or vehicle into one of the above brain regions. After additional extinction training in the extinction context, reinstatement of cocaine-seeking behavior (i.e., non-reinforced lever presses) was assessed in the cocaine-paired context. Tetrodotoxin, but not anisomycin, administered into the DH inhibited drug context-induced cocaine-seeking behavior in a memory reactivation-dependent manner. Other manipulations failed to alter this behavior. These findings suggest that the DH facilitates the reconsolidation of associative memories that maintain context-induced cocaine-seeking behavior, but it is not the site of anisomycin-sensitive memory restabilization per se.
机译：暴露于可卡因配对的环境会增加可卡因使用者的复发倾向，并促使大鼠寻求可卡因。根据重新整合假说，在重新暴露环境时，已建立的与可卡因相关的关联会被检索并变得不稳定。这些协会必须重新整合到长期记忆中，以实现持久的刺激控制。背海马（DH），背外侧尾状-丘脑和背侧前额叶皮层对于情境诱导的可卡因寻求表达的表达至关重要，并且这些大脑区域也可能在可卡因相关记忆的巩固中发挥作用，从而促进这种行为。为了检验这一假设，对大鼠进行了训练，以在不同的环境情况下（可卡因配对的情况下）按压无信号可卡因输注的杠杆（0.2 mg /输液，静脉内注射），然后在不同的情况下（消灭环境）进行灭绝训练。然后将大鼠重新暴露于可卡因配对的环境中15分钟，以重新激活可卡因相关的记忆或可比暴露于新型未配对环境。此后即刻，大鼠接受上述蛋白质合成抑制剂茴香霉素，钠通道阻滞剂河豚毒素或媒介物的双侧微输注至上述脑区之一。在灭绝环境中进行了额外的灭绝训练后，在可卡因配对的情况下评估了可卡因寻找行为的恢复（即，非强化杠杆按压）。 DH中施用河豚毒素，但不使用茴香霉素，以记忆再激活依赖性方式抑制药物环境诱导的可卡因寻找行为。其他操作未能更改此行为。这些发现表明，DH促进了关联记忆的重建，这些记忆维持了情境诱导的可卡因寻找行为，但它本身并不是茴香霉素敏感的记忆再稳定化的场所。

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