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首页> 外文期刊>The European Journal of Neuroscience >Sound stimulation modulates high-threshold K(+) currents in mouse auditory brainstem neurons.
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Sound stimulation modulates high-threshold K(+) currents in mouse auditory brainstem neurons.

机译：声音刺激调节小鼠听觉脑干神经元中的高阈值K（+）电流。

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摘要

The auditory system provides a valuable experimental model to investigate the role of sensory activity in regulating neuronal membrane properties. In this study, we have investigated the role of activity directly by measuring changes in medial nucleus of the trapezoid body (MNTB) neurons in normal hearing mice subjected to 1-h sound stimulation. Broadband (4-12 kHz) chirps were used to activate MNTB neurons tonotopically restricted to the lateral MNTB, as confirmed by c-Fos-immunoreactivity. Following 1-h sound stimulation a substantial increase in Kv3.1b-immunoreactivity was measured in the lateral region of the MNTB, which lasted for 2 h before returning to control levels. Electrophysiological patch-clamp recordings in brainstem slices revealed an increase in high-threshold potassium currents in the lateral MNTB of sound-stimulated mice. Current-clamp and dynamic-clamp experiments showed that MNTB cells from the sound-stimulated mice were able to maintain briefer action potentials during high-frequency firing than cells from control mice. These results provide evidence that acoustically driven auditory activity can selectively regulate high-threshold potassium currents in the MNTB of normal hearing mice, likely due to an increased membrane expression of Kv3.1b channels.
机译：听觉系统提供了有价值的实验模型，以研究感觉活动在调节神经元膜特性中的作用。在这项研究中，我们已经通过测量受到1-h声音刺激的正常听力小鼠的梯形体（MNTB）神经元内侧核的变化来直接研究活性的作用。 c-Fos-免疫反应性证实，宽带（4-12 kHz）线性调频脉冲被用于激活MNTB神经元，从而局限在侧向MNTB。经过1小时的声音刺激后，在MNTB的侧面区域中检测到Kv3.1b免疫反应性显着增加，持续了2小时后才恢复到对照水平。脑干切片中的电生理膜片钳记录表明，声音刺激小鼠的外侧MNTB中高阈值钾电流增加。电流钳和动态钳实验表明，声音刺激小鼠的MNTB细胞在高频发射过程中能够比对照小鼠的细胞保持更短的动作电位。这些结果提供了证据，表明声学驱动的听觉活动可以选择性调节正常听力小鼠的MNTB中的高阈值钾电流，这可能是由于Kv3.1b通道膜表达增加所致。

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