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首页> 外文期刊>The European Journal of Neuroscience >Reelin induces a common signal for spinal cord and cerebral cortical migration (commentary on Kruger et al.).
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Reelin induces a common signal for spinal cord and cerebral cortical migration (commentary on Kruger et al.).

机译:Reelin诱导脊髓和大脑皮层迁移的共同信号(Kruger等人评论)。

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摘要

Non-invasive methods of brain stimulation in humans such as repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (TDCS) have emerged as powerful research tools to study and manipulate cortical plasticity in the human brain (Ziemann et al, 2008). Both rTMS and TDCS have been successfully used to augment training-induced plasticity (Reis et al, 2008). This feature is of particular interest for current attempts to use transcranial brain stimulation therapeutically, for instance to facilitate post-stroke recovery (Bolognini et al., 2009). One prominent strategy is to optimize training-induced plastic changes by priming the cortical area involved in learning. Indeed there is evidence that this priming approach can enhance training-related plasticity and boost learning in humans, yet only a small number of studies have addressed the underlying neurobiological mechanisms in animal studies (e.g. Fritsch et al, 2010). While current research focuses on changes in synaptic and intrinsic excitability in excitatory glutamatergic neurons, the conditioning effects of transcranial stimulation techniques on the activity of inhibitory interneurons has received little attention.
机译:重复性经颅磁刺激(rTMS)或经颅直流电刺激(TDCS)等非人性脑刺激方法已成为研究和操纵人脑皮质可塑性的强大研究工具(Ziemann等,2008)。 rTMS和TDCS已成功用于增强训练诱导的可塑性(Reis等,2008)。对于当前尝试在治疗上使用经颅脑刺激,例如促进中风后恢复的尝试,此功能特别受关注(Bolognini等,2009)。一种重要的策略是通过灌注学习中涉及的皮层区域来优化训练引起的可塑性变化。确实有证据表明这种启动方法可以增强与训练相关的可塑性并促进人类学习,但只有少数研究解决了动物研究中潜在的神经生物学机制(例如Fritsch等人,2010年)。虽然目前的研究集中在兴奋性谷氨酸能神经元的突触和内在兴奋性的变化,但经颅刺激技术对抑制性中间神经元活性的调节作用却很少受到关注。

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