...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Neocortical synaptophysin asymmetry and behavioral lateralization in chimpanzees (Pan troglodytes).
【24h】

Neocortical synaptophysin asymmetry and behavioral lateralization in chimpanzees (Pan troglodytes).

机译：黑猩猩（潘氏穴居人）的新皮层突触素不对称和行为偏侧化。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although behavioral lateralization is known to correlate with certain aspects of brain asymmetry in primates, there are limited data concerning hemispheric biases in the microstructure of the neocortex. In the present study, we investigated whether there is asymmetry in synaptophysin-immunoreactive puncta density and protein expression levels in the region of hand representation of the primary motor cortex in chimpanzees (Pan troglodytes). Synaptophysin is a presynaptic vesicle-associated protein found in nearly all synapses of the central nervous system. We also tested whether there is a relationship between hand preference on a coordinated bimanual task and the interhemispheric distribution of synaptophysin as measured by both stereologic counts of immunoreactive puncta and by Western blotting. Our results demonstrated that synaptophysin-immunoreactive puncta density is not asymmetric at the population level, whereas synaptophysin protein expression levels are significantly higher in the right hemisphere. Handedness was correlated with interindividual variation in synaptophysin-immunoreactive puncta density. As a group, left-handed and ambidextrous chimpanzees showed a rightward bias in puncta density. In contrast, puncta densities were symmetrical in right-handed chimpanzees. These findings support the conclusion that synapse asymmetry is modulated by lateralization of skilled motor behavior in chimpanzees.
机译：尽管已知行为偏侧化与灵长类动物大脑不对称的某些方面相关，但有关新皮层微观结构中半球偏见的数据有限。在本研究中，我们调查了在黑猩猩（Pan穴居人）的主要运动皮层的手部代表区域中突触素-免疫反应性小点密度和蛋白质表达水平是否存在不对称性。突触素是在几乎所有中枢神经系统突触中发现的突触前囊泡相关蛋白。我们还测试了通过协调的双向任务进行的手偏爱与突触素的半球间分布是否存在相关性，如通过免疫反应性点状体的立体计数和蛋白质印迹法所测量的。我们的结果表明，突触素免疫反应点的密度在人群水平上并非不对称，而在右半球，突触素蛋白的表达水平明显更高。惯性与突触素-免疫反应性小点密度的个体差异相关。作为一个整体，左手和灵巧的黑猩猩在点状点密度上表现出向右偏斜。相反，右撇子黑猩猩的小点密度是对称的。这些发现支持这样的结论，即黑猩猩熟练的运动行为的偏侧化可调节突触的不对称性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号