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首页> 外文期刊>The European Journal of Neuroscience >Artificial feeding synchronizes behavioral, hormonal, metabolic and neural parameters in mother-deprived neonatal rabbit pups.
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Artificial feeding synchronizes behavioral, hormonal, metabolic and neural parameters in mother-deprived neonatal rabbit pups.

机译：人工喂养可以使母亲被剥夺的新生幼犬的行为，激素，代谢和神经参数同步化。

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Nursing in the rabbit is under circadian control, and pups have a daily anticipatory behavioral arousal synchronized to this unique event, but it is not known which signal is the main entraining cue. In the present study, we hypothesized that food is the main entraining signal. Using mother-deprived pups, we tested the effects of artificial feeding on the synchronization of locomotor behavior, plasma glucose, corticosterone, c-Fos (FOS) and PERIOD1 (PER1) rhythms in suprachiasmatic, supraoptic, paraventricular and tuberomammillary nuclei. At postnatal day 1, an intragastric tube was placed by gastrostomy. The next day and for the rest of the experiment, pups were fed with a milk formula through the cannula at either 02:00 h or 10:00 h [feeding time = zeitgeber time (ZT)0]. At postnatal days 5-7, pups exhibited behavioral arousal, with a significant increase in locomotor behavior 60 min before feeding. Glucose levels increased after feeding, peaking at ZT4-ZT12 and then declining. Corticosterone levels were highest around the time of feeding, and then decreased to trough concentrations at ZT12-ZT16, increasing again in anticipation of the next feeding bout. In the brain, the suprachiasmatic nucleus had a rhythm of FOS and PER1 that was not significantly affected by the feeding schedule. Conversely, the supraoptic, paraventricular and tuberomammillary nuclei had rhythms of both FOS and PER1 induced by the time of scheduled feeding. We conclude that the nursing rabbit pup is a natural model of food entrainment, as food, in this case milk formula, is a strong synchronizing signal for behavioral, hormonal, metabolic and neural parameters.
机译：兔子的护理处于昼夜节律的控制之下，幼崽每天都有与这种独特事件同步的预期行为唤醒，但尚不清楚哪个信号是主要的诱因。在本研究中，我们假设食物是主要的夹带信号。我们使用母亲剥夺的幼崽，测试了人工喂养对视交叉上，视上，心室旁和结节性乳头状核运动行为，血浆葡萄糖，皮质酮，c-Fos（FOS）和PERIOD1（PER1）节律同步的影响。出生后第1天，通过胃造口术置入胃内导管。第二天以及实验的其余部分，在02:00或10:00时通过插管给幼犬喂饲牛奶配方奶[喂食时间= Zeitgeber时间（ZT）0]。在出生后的第5-7天，幼犬表现出行为唤起，进食前60分钟的运动行为显着增加。进食后葡萄糖水平升高，在ZT4-ZT12达到峰值，然后下降。皮质类固醇水平在进食时最高，然后在ZT12-ZT16降至谷浓度，并因预期下一次进食而再次增加。在大脑中，视交叉上核的FOS和PER1的节律不受进食时间表的影响。相反，在计划喂食时，视上，心室旁和结核母乳核都有FOS和PER1的节律。我们得出的结论是，哺乳兔幼崽是食物摄入的自然模型，因为食物（在这种情况下为牛奶配方）是行为，激素，代谢和神经参数的强烈同步信号。

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