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首页> 外文期刊>The European Journal of Neuroscience >Corticomotor representation to a human forearm muscle changes following cervical spinal cord injury.
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Corticomotor representation to a human forearm muscle changes following cervical spinal cord injury.

机译：颈脊髓损伤后，对人类前臂肌肉的皮质运动表现改变。

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Functional imaging studies, using blood oxygen level-dependent signals, have demonstrated cortical reorganization of forearm muscle maps towards the denervated leg area following spinal cord injury (SCI). The extent of cortical reorganization was predicted by spinal atrophy. We therefore expected to see a similar shift in the motor output of corticospinal projections of the forearm towards more denervated lower body parts in volunteers with cervical injury. Therefore, we used magnetic resonance imaging-navigated transcranial magnetic stimulation (TMS) to non-invasively measure changes in cortical map reorganization of a forearm muscle in the primary motor cortex (M1) following human SCI. We recruited volunteers with chronic cervical injuries resulting in bilateral upper and lower motor impairment and severe cervical atrophy and healthy control participants. All participants underwent a T1-weighted anatomical scan prior to the TMS experiment. The motor thresholds of the extensor digitorum communis muscle (EDC) were defined, and its cortical muscle representation was mapped. The centre of gravity (CoG), the cortical silent period (CSP) and active motor thresholds (AMTs) were measured. Regression analysis was used to investigate relationships between trauma-related anatomical changes and TMS parameters. SCI participants had increased AMTs (P = 0.01) and increased CSP duration (P = 0.01). The CoG of the EDC motor-evoked potential map was located more posteriorly towards the anatomical hand representation of M1 in SCI participants than in controls (P = 0.03). Crucially, cord atrophy was negatively associated with AMT and CSP duration (r(2) >/= 0.26, P < 0.05). In conclusion, greater spinal cord atrophy predicts changes at the cortical level that lead to reduced excitability and increased inhibition. Therefore, cortical forearm motor representations may reorganize towards the intrinsic hand motor representation to maximize output to muscles of the impaired forearm following SCI.
机译：使用血氧水平依赖性信号的功能成像研究表明，脊髓损伤（SCI）后，前臂肌肉图的皮层组织朝着神经支配的腿部区域重组。皮质重组的程度是由脊髓萎缩预测的。因此，我们希望在患有颈椎病的志愿者中，前臂的皮质脊髓突部的运动输出朝着更神经支配的下半身部位发生类似的变化。因此，我们使用磁共振成像导航经颅磁刺激（TMS）来无创地测量人类SCI后前运动皮层（M1）中前臂肌肉的皮质图重组的变化。我们招募了患有慢性宫颈损伤的志愿者，这些志愿者导致双侧上，下运动障碍，严重的宫颈萎缩和健康对照者。在TMS实验之前，所有参与者都要进行T1加权解剖扫描。定义了指趾伸肌（EDC）的运动阈值，并绘制了其皮层肌肉的图示。测量了重心（CoG），皮层无声周期（CSP）和活动电机阈值（AMT）。回归分析用于研究创伤相关解剖变化与TMS参数之间的关系。 SCI参与者的AMT增加（P = 0.01），CSP持续时间增加（P = 0.01）。与对照组相比，EDC运动诱发电位图的CoG位于SCI参与者中朝向M1的解剖手表示更靠后的位置（P = 0.03）。至关重要的是，脊髓萎缩与AMT和CSP持续时间呈负相关（r（2）> / = 0.26，P <0.05）。总之，更大的脊髓萎缩可预测皮质水平的变化，从而导致兴奋性降低和抑制作用增强。因此，SCI后，皮质前臂运动表现可能会向内在手运动表现重新组织，以最大程度地输出到受损前臂的肌肉。

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