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首页> 外文期刊>The European Journal of Neuroscience >The role of dopamine in the accumbens core in the expression of pavlovian-conditioned responses
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The role of dopamine in the accumbens core in the expression of pavlovian-conditioned responses

机译：多巴胺在伏伏核反应中表达伏伏核的作用

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The role of dopamine in reward is a topic of debate. For example, some have argued that phasic dopamine signaling provides a prediction-error signal necessary for stimulus-reward learning, whereas others have hypothesized that dopamine is not necessary for learning per se, but for attributing incentive motivational value ('incentive salience') to reward cues. These psychological processes are difficult to tease apart, because they tend to change together. To disentangle them we took advantage of natural individual variation in the extent to which reward cues are attributed with incentive salience, and asked whether dopamine (specifically in the core of the nucleus accumbens) is necessary for the expression of two forms of Pavlovian-conditioned approach behavior - one in which the cue acquires powerful motivational properties (sign-tracking) and another closely related one in which it does not (goal-tracking). After acquisition of these conditioned responses (CRs), intra-accumbens injection of the dopamine receptor antagonist flupenthixol markedly impaired the expression of a sign-tracking CR, but not a goal-tracking CR. Furthermore, dopamine antagonism did not produce a gradual extinction-like decline in behavior, but maximally impaired expression of a sign-tracking CR on the very first trial, indicating the effect was not due to new learning (i.e. it occurred in the absence of new prediction-error computations). The data support the view that dopamine in the accumbens core is not necessary for learning stimulus-reward associations, but for attributing incentive salience to reward cues, transforming predictive conditional stimuli into incentive stimuli with powerful motivational properties.
机译：多巴胺在奖励中的作用是一个争论的话题。例如，有些人认为，多巴胺的阶段性信号提供了奖励学习所必需的预测误差信号，而另一些人则认为，多巴胺本身并不是学习所必需的，而是将激励动机价值（“激励显着性”）归因于奖励提示。这些心理过程很难分开，因为它们往往一起变化。为了弄清它们，我们利用了自然的个体差异，将奖励线索与激励显着性联系起来，并询问多巴胺（特别是伏伏核的核心）对于表达两种形式的巴甫洛夫条件法是否必要行为-一种提示获得强大的动机特性（符号跟踪），另一种紧密关联而没有（目标跟踪）。在获得这些条件反应（CR）后，向多巴胺受体拮抗剂氟喷他索的伏耳内注射明显损害了体征追踪CR的表达，但没有损害目标追踪CR的表达。此外，多巴胺拮抗作用并未导致行为逐渐消失，但在首次试验中最大程度地削弱了体征追踪CR的表达，这表明该效应并非源于新的学习（即，在没有新的学习的情况下发生）。预测误差计算）。数据支持这样的观点，伏隔核中的多巴胺对于学习刺激与奖励的联系不是必需的，而是将奖励显着性归因于奖励线索，将预测性条件性刺激转化为具有强大动机属性的奖励性刺激。

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