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首页> 外文期刊>The European Journal of Neuroscience >Influence of constraint-induced movement therapy upon evoked potentials in rats with cerebral infarction
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Influence of constraint-induced movement therapy upon evoked potentials in rats with cerebral infarction

机译：约束诱导运动疗法对脑梗死大鼠诱发电位的影响

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Constraint-induced movement therapy (CIMT) is an effective treatment promoting motor recovery of upper extremity function in stroke patients. The objective of the present study was to determine the effect of CIMT on the evoked potentials in rats with focal cerebral cortical ischemia induced by endothelin-1 (ET-1). Thirty rats were randomly assigned to the sham, infarct or CIMT groups. ET-1 was injected stereotaxically into the forelimb area of the cerebral cortex in the dominant hemisphere. Custom-made constraint jackets were applied to limit movement of the unaffected forelimb in the CIMT group. Motor and sensory function of the forelimb was evaluated by a pellet retrieval task and forearm asymmetry test. Electrophysiologic changes were evaluated by motor-evoked potentials (MEPs) and somatosensory-evoked potentials (SEPs). The location and extent of cerebral ischemia were confirmed and compared histologically. The CIMT group showed better recovery in the pellet retrieval task. Forelimb use was more symmetrical in the CIMT group. The waveform of the SEP was reversed and delayed in the infarct group, but it was preserved in the CIMT group with amplitude decrease only. The estimated volume of infarction was smaller in the CIMT group, although statistically not significant. The results demonstrate that CIMT can promote recovery of motor function in focal cerebral cortical infarcts, and that recovery may be related to reorganization of the cerebral neuronal network in the somatosensory pathway. Constraint-induced movement therapy (CIMT) hastened motor recovery in rats with focal cerebral infarction induced by endothelin-1. CIMT also affected the waveforms of the somatosensory evoked potentials (SEPs). Reversal and delay of P1 peak was evident in the infarct group, but not in the CIMT group. The results demonstrate that the CIMT may facilitate reorganization of the cerebral neuronal network related to the somatosensory pathway.
机译：约束诱导运动疗法（CIMT）是促进卒中患者上肢运动功能恢复的有效疗法。本研究的目的是确定CIMT对由内皮素1（ET-1）诱发的局灶性大脑皮质缺血大鼠诱发电位的影响。将30只大鼠随机分为假，梗死或CIMT组。将ET-1立体定向注射到优势半球大脑皮质的前肢区域。使用定制的约束夹克来限制CIMT组中未受影响的前肢的运动。前肢的运动和感觉功能通过药丸检索任务和前臂不对称测试进行评估。通过运动诱发电位（MEP）和体感诱发电位（SEP）评估电生理变化。确认脑缺血的位置和程度，并进行组织学比较。 CIMT组在颗粒物回收任务中显示出更好的恢复。 CIMT组中前肢的使用更为对称。在梗死组中，SEP的波形反转并延迟，但在CIMT组中保留，仅振幅降低。尽管在统计学上不显着，但CIMT组的估计梗死面积较小。结果表明，CIMT可以促进局灶性大脑皮层梗塞运动功能的恢复，并且恢复可能与体感通路中脑神经元网络的重组有关。约束诱导运动疗法（CIMT）促进了内皮素1诱发的局灶性脑梗死大鼠的运动恢复。 CIMT还影响了体感诱发电位（SEP）的波形。 P1峰的逆转和延迟在梗死组中很明显，但在CIMT组中则没有。结果表明，CIMT可能促进与体感通路相关的大脑神经元网络的重组。

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