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首页> 外文期刊>The European Journal of Neuroscience >Timing of developmental sequences in different brain structures: Physiological and pathological implications
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Timing of developmental sequences in different brain structures: Physiological and pathological implications

机译：不同大脑结构中发育序列的时间：生理和病理学意义

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The developing brain is not a small adult brain. Voltage- and transmitter-gated currents, like network-driven patterns, follow a developmental sequence. Studies initially performed in cortical structures and subsequently in subcortical structures have unravelled a developmental sequence of events in which intrinsic voltage-gated calcium currents are followed by nonsynaptic calcium plateaux and synapse-driven giant depolarising potentials, orchestrated by depolarizing actions of GABA and long-lasting NMDA receptor-mediated currents. The function of these early patterns is to enable heterogeneous neurons to fire and wire together rather than to code specific modalities. However, at some stage, behaviourally relevant activities must replace these immature patterns, implying the presence of programmed stop signals. Here, we show that the developing striatum follows a developmental sequence in which immature patterns are silenced precisely when the pup starts locomotion. This is mediated by a loss of the long-lasting NMDA-NR2C/D receptor-mediated current and the expression of a voltage-gated K + current. At the same time, the descending inputs to the spinal cord become fully functional, accompanying a GABA/glycine polarity shift and ending the expression of developmental patterns. Therefore, although the timetable of development differs in different brain structures, the g sequence is quite similar, relying first on nonsynaptic events and then on synaptic oscillations that entrain large neuronal populations. In keeping with the 'neuroarcheology' theory, genetic mutations or environmental insults that perturb these developmental sequences constitute early signatures of developmental disorders. Birth dating developmental disorders thus provides important indicators of the event that triggers the pathological cascade leading ultimately to disease. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
机译：发育中的大脑不是成年人的大脑。电压和发射机门控电流，如网络驱动模式，遵循发展顺序。最初在皮质结构中进行的研究，随后在皮质下结构中进行的研究揭示了事件的发展顺序，其中固有电压门控钙电流，非突触钙平台电流和突触驱动的巨大去极化电位，其由GABA的去极化作用和长效作用精心策划NMDA受体介导的电流。这些早期模式的功能是使异类神经元能够发射并连接在一起，而不是编码特定的形式。但是，在某个阶段，行为相关的活动必须替换这些不成熟的模式，这意味着存在已编程的停止信号。在这里，我们显示发育的纹状体遵循发育顺序，其中当幼犬开始运动时，未成熟模式被精确沉默。这是由持久的NMDA-NR2C / D受体介导的电流的丢失和电压门控K +电流的表达介导的。同时，伴随着GABA /甘氨酸极性移动并终止发育模式的表达，脊髓的下降输入变得完全功能正常。因此，尽管在不同的大脑结构中发育的时间表有所不同，但g序列非常相似，首先依赖于非突触事件，然后依赖于携带大量神经元种群的突触振荡。与“神经考古学”理论保持一致，扰乱这些发育序列的遗传突变或环境侮辱构成了发育障碍的早期特征。因此，出生约会发育障碍提供了事件的重要指标，该事件触发了最终导致疾病的病理级联。 2012年发布。本文是美国政府的工作，在美国属于公共领域。

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