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首页> 外文期刊>The European Journal of Neuroscience >Novel biochemical manipulation of brain serotonin reveals a role of serotonin in the circadian rhythm of sleep-wake cycles
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Novel biochemical manipulation of brain serotonin reveals a role of serotonin in the circadian rhythm of sleep-wake cycles

机译：脑5-羟色胺的新型生化处理揭示了5-羟色胺在睡眠-觉醒周期的昼夜节律中的作用

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Serotonin (5-HT) neurons have been implicated in the modulation of many physiological functions, including mood regulation, feeding, and sleep. Impaired or altered 5-HT neurotransmission appears to be involved in depression and anxiety symptoms, as well as in sleep disorders. To investigate brain 5-HT functions in sleep, we induced 5-HT deficiency through acute tryptophan depletion in rats by intraperitoneally injecting a tryptophan-degrading enzyme called tryptophan side chain oxidase I (TSOI). After the administration of TSOI (20 units), plasma tryptophan levels selectively decreased to 1-2% of those of controls within 2h, remained under 1% for 12-24h, and then recovered between 72 and 96h. Following plasma tryptophan levels, brain 5-HT levels decreased to ~30% of the control level after 6h, remained at this low level for 20-30h, and returned to normal after 72h. In contrast, brain norepinephreine and dopamine levels remained unchanged. After TSOI injection, the circadian rhythms of the sleep-wake cycle and locomotive activity were lost and broken into minute(s) ultradian alternations. The hourly slow-wave sleep (SWS) time significantly increased at night, but decreased during the day, whereas rapid eye movement sleep was significantly reduced during the day. However, daily total (cumulative) SWS time was retained at the normal level. As brain 5-HT levels gradually recovered 48h after TSOI injection, the circadian rhythms of sleep-wake cycles and locomotive activity returned to normal. Our results suggest that 5-HT with a rapid turnover rate plays an important role in the circadian rhythm of sleep-wake cycles.
机译：血清素（5-HT）神经元与许多生理功能的调节有关，包括情绪调节，进食和睡眠。 5-HT神经传递受损或改变似乎与抑郁和焦虑症状以及睡眠障碍有关。为了研究大脑中5-HT在睡眠中的功能，我们通过腹膜内注射称为色氨酸侧链氧化酶I（TSOI）的色氨酸降解酶，通过急性色氨酸耗竭诱导大鼠5-HT缺乏。施用TSOI（20个单位）后，血浆色氨酸水平在2小时内选择性降低至对照水平的1-2％，在1％以下保持12-24h，然后在72至96h之间恢复。血浆中的色氨酸水平升高后，脑5-HT水平在6h后降至对照水平的〜30％，在此低水平保持20-30h，并在72h后恢复正常。相反，脑中去甲肾上腺素和多巴胺水平保持不变。注射TSOI后，睡眠-觉醒周期的昼夜节律和机车活动消失，并分解成分钟的超昼夜交替。每小时的慢波睡眠（SWS）时间在晚上显着增加，但是在白天却减少了，而白天快速眼动睡眠显着减少了。但是，每天的总（累积）SWS时间保持在正常水平。 TSOI注射后48小时，脑部5-HT水平逐渐恢复，睡眠觉醒周期和机车活动的昼夜节律恢复正常。我们的结果表明，具有快速更新率的5-HT在睡眠-觉醒周期的昼夜节律中起重要作用。

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