...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Pharmacological mechanisms underlying switching from the large-scale depolarization wave to segregated activity in the mouse central nervous system
【24h】

Pharmacological mechanisms underlying switching from the large-scale depolarization wave to segregated activity in the mouse central nervous system

机译：小鼠中枢神经系统从大规模去极化波转换为分离活动的潜在药理机制

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

During the early development of the nervous system, synchronized activity is observed in a variety of structures, and is considered to play a fundamental role in neural development. One of the most striking examples of such activity is the depolarization wave reported in chick and rat embryos. In the accompanying paper (Momose-Sato, 2012), we have demonstrated that a depolarization wave is also present in the mouse embryo by showing large-scale optical waves, which spread remarkably over the central nervous system, including the spinal cord, hindbrain, cerebellum, midbrain, and forebrain. In the present study, we examined the pharmacological nature of the mouse depolarization wave and its developmental changes. We show here that two types of switching in pharmacological characteristics occur during development. One is that the depolarization wave is strongly dependent on nicotinic acetylcholine receptors during the early developmental stage [embryonic day (E)11-12], but is dominated by glutamate at the later stage (E13 onwards). The second is that γ-aminobutyric acid (GABA), which acts as an excitatory mediator of the depolarization wave during the early phase, becomes an inhibitory modulator by E14. These changes seemed to occur earlier in the hindbrain than in the spinal cord. Furthermore, we show that the second switch causes the loss of synchronization over the network, resulting in the disappearance of the depolarization wave and segregation of the activity into discrete regions of the medulla and spinal cord. We suggest that pharmacological switching is a possible mechanism underlz.
机译：在神经系统的早期发育期间，在各种结构中观察到同步活动，并且被认为在神经发育中起着基本作用。这种活性最明显的例子之一是在鸡和大鼠胚胎中报告的去极化波。在随附的论文（Momose-Sato，2012年）中，我们通过显示大规模的光波（其广泛分布于中枢神经系统，包括脊髓，后脑，小脑，中脑和前脑。在本研究中，我们检查了小鼠去极化波的药理性质及其发育变化。我们在这里显示在开发过程中发生了两种类型的药理特性转换。一个是去极化波在发育的早期阶段[胚胎日（E）11-12]强烈依赖于烟碱乙酰胆碱受体，但在后期阶段（E13以后）主要由谷氨酸控制。第二个原因是，γ-氨基丁酸（GABA）在早期阶段起去极化波的兴奋性介质的作用，成为E14的抑制性调节剂。这些改变似乎在后脑中比在脊髓中更早发生。此外，我们表明第二个开关会导致网络失去同步，从而导致去极化波的消失以及活动分离到髓质和脊髓的离散区域。我们建议药理转换是可能的机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号