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首页> 外文期刊>The European Journal of Neuroscience >Lesions of the dorsal striatum impair orienting behaviour of salamanders without affecting visual processing in the tectum
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Lesions of the dorsal striatum impair orienting behaviour of salamanders without affecting visual processing in the tectum

机译：背侧纹状体病变损害sal的定向行为而不影响顶盖的视觉处理

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In amphibians, visual information in the midbrain tectum is relayed via the thalamus to telencephalic centres. Lesions of the dorsal thalamus of the salamander Plethodon shermani result in impairment of orienting behaviour and in modulation of spike pattern of tectal neurons. These effects may be induced by an interruption of a tectum-thalamus-telencephalon-tectum feedback loop enabling spatial attention and selection of visual objects. The striatum is a potential candidate for involvement in this pathway; accordingly, we investigated the effects of lesioning the dorsal striatum. Compared to controls and sham lesioned salamanders, striatum-lesioned animals exhibited a significantly lower number of orienting responses toward one of two competing prey stimuli. Orienting towards stimuli was impaired, while the spike pattern of tectal cells was unaffected, because both in controls and striatum-lesioned salamanders the spike number significantly decreased at presentation of one prey stimulus inside the excitatory receptive field and another one in the surround compared to that at single presentation inside the excitatory receptive field. We conclude that the dorsal striatum contributes to orienting behaviour, but not to an inhibitory feedback signal onto tectal neurons. The brain area engaged in the feedback loop during visual object discrimination and selection has yet to be identified. Information processing in the amphibian striatum includes multisensory integration; the striatum generates behavioural patterns that influence (pre)motor processing in the brainstem. This situation resembles the situation found in rats, in which the dorsolateral striatum is involved in stimulus-response learning regardless of the sensory modality, as well as in habit formation.
机译：在两栖动物中，中脑盖层的视觉信息通过丘脑传递到端脑中枢。 PPlethodon shermani背丘脑的病变导致定向行为的损害和顶盖神经元的尖峰模式的调制。这些影响可能是由于使丘脑-丘脑-脑脑-皮质反馈回路中断而引起的，从而引起了空间注意力和视觉对象的选择。纹状体是参与该途径的潜在候选者。因此，我们调查了损害纹状体背侧的作用。与对照组和假病变sal相比，纹状体病变动物对两种竞争猎物刺激之一的定向反应数量明显减少。朝向刺激的方向受到损害，而顶盖细胞的尖峰模式不受影响，因为在对照组和纹状体sal中，在兴奋性感受野内出现一种猎物刺激时，与周围相比，尖峰数目明显减少，而顶盖数目却明显减少。在兴奋性感受野内的一次陈述。我们得出的结论是，背侧纹状体有助于定向行为，但对顶盖神经元无抑制性反馈信号。在视觉对象辨别和选择期间参与反馈回路的大脑区域尚未确定。两栖类纹状体中的信息处理包括多感官整合。纹状体产生影响脑干运动过程的行为模式。这种情况类似于在大鼠中发现的情况，在这种情况下，背侧纹状体参与刺激反应学习，而与感觉方式无关，并且参与习惯形成。

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